Effect of vitamin B6 deficiency on antioxidative status in rats with exercise-induced oxidative stress

This study investigated the effect of vitamin B-6 deficiency oil antioxidant enzyme activities and lipid profile in rats with exercise-induced oxidative stress. Forty eight rats were fed either a vitamin B-6 deficient diet (B6-) or a control diet (control) for 4 weeks and then subdivided into 3 groups: pre-exercise (PreE) post-exercise (PostE): recess after exercise (recessE). Compared to those of control group, plasma catalase and hepatic cytosol Superoxide dismutase (SOD, EC 1.15.1.1) activities of B6- group were lower regardless of exercise. The ratio of reduced glutathione/oxidized glutathione (GSH/GSSG) of B-6 - group was lower in PreE and there was no difference between PostE and recessE. The level of malondialdehyde (MDA) of B6- was significantly higher in PreE and PostE. High-density lipoprotein-cholesterol (HDL-C) level of B6- group was lower regardless of exercise. Atherosclerotic index of B6- group was higher in PreE and there was no difference between PostE and recessE. It is suggested that a reduction in antioxidative Status Caused by vitamin B-6 deficiency may be aggravated under exercise-induced oxidative stress.