α1-Blockers in Men with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction: Is Silodosin Different?

被引：14

作者：

Roehrborn, Claus G. ^{[1
]}

Cruz, Francisco ^{[2
,3
]}

Fusco, Ferdinando ^{[4
]}

机构：

[1] Univ Texas Southwestern Med Ctr, Dept Urol, Dallas, TX USA

[2] Hosp Sao Joao, Dept Urol, Oporto, Portugal

[3] Univ Naples Federico II, Dept Urol, Naples, Italy

[4] Univ Porto, Fac Med, Dept Renal Urol & Infect Dis, Oporto, Portugal

来源：

ADVANCES IN THERAPY | 2017年 / 33卷 / 12期

关键词：

Alpha-blockers; Silodosin; Urology; INDIVIDUAL PATIENT DATA; ALPHA(1)-ADRENOCEPTOR ANTAGONISTS; HYPERPLASIA BPH; DOUBLE-BLIND; ALPHA(1A)-ADRENOCEPTOR-SELECTIVE ANTAGONIST; REGISTRATIONAL TRIALS; NOCTURNAL POLYURIA; METAANALYSIS; EFFICACY; PLACEBO;

D O I：

10.1007/s12325-016-0423-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Available alpha 1-blockers (ABs) have different profiles of receptor selectivity. Silodosin exhibits the highest selectivity for the alpha(1A) adrenergic receptor. This pharmacological feature couples with a singular urodynamic and clinical profile. The magnitude of bladder outlet obstruction improvement in patients receiving silodosin is higher if compared to other ABs. From a clinical point of view, current evidence suggests an advantage in favor of silodosin in terms of nocturia improvement and cardiovascular safety. The incidence of ejaculatory dysfunction with silodosin is higher compared to other Abs.

引用

页码：2110 / 2121

页数：12

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