Nigrostriatal Upregulation of 5-HT2A Receptors Correlates with Motor Dysfunction in Progressive Supranuclear Palsy

被引：12

作者：

Stamelou, Maria ^{[1
,2
]}

Matusch, Andreas ^{[1
,2
]}

Elmenhorst, David ^{[2
]}

Hurlemann, Rene ^{[3
]}

Eggert, Karla M. ^{[1
]}

Zilles, Karl ^{[2
,4
]}

Oertel, Wolfgang H. ^{[1
]}

Hoeglinger, Guenter U. ^{[1
]}

Bauer, Andreas ^{[2
,5
]}

机构：

[1] Univ Marburg, Dept Neurol, D-35039 Marburg, Germany

[2] Forschungszentrum Julich, Inst Neurosci & Biophys Med INB3, D-52425 Julich, Germany

[3] Univ Bonn, Dept Psychiat, D-5300 Bonn, Germany

[4] Univ Dusseldorf, C&O Vogt Inst Brain Res, Dusseldorf, Germany

[5] Univ Dusseldorf, Dept Neurol, D-4000 Dusseldorf, Germany

来源：

MOVEMENT DISORDERS | 2009年 / 24卷 / 08期

关键词：

PSP; Steele-Richardson-Olszewski syndrome; serotonin; 5-HT; 5-HT2A receptor; PET; PARKINSONS-DISEASE; BRAIN; DISORDERS; NEURONS; SCALE;

D O I：

10.1002/mds.22533

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A dysfunction of multiple neurotransmitter systems is assumed as a neurochemical basis of the akinetic-rigid syndrome of progressive supranuclear palsy (PSP). In vitro studies have produced conflicting results on the serotoninergic system in PSP. We, therefore, studied the binding potential of the serotonin 2A (5-HT2A) receptor ligand [F-18]altanserin in 8 patients with clinically probable PSP and 13 healthy controls using positron emission tomography. We found an up-regulation of 5-HT2A receptors in the substantia nigra and, to a lower degree, in the striatum, while neocortical 5-HT2A receptor densities showed no changes upon partial-volume correction. Nigral and striatal receptor changes were significantly correlated with patients' scores of motor dysfunction (UPDRS III, PSP-rating scale) pointing to a functional relevance of the described findings. (C) 2009 Movement Disorder Society

引用

页码：1170 / 1175

页数：6

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