Vpr-Induced DNA Double-Strand Breaks: Molecular Mechanism and Biological Relevance

被引：5
作者：
Nakai-Murakami, Chikako [1 ]
Minemoto, Yuzuru [1 ]
Ishizaka, Yukihito [1 ]
机构：
[1] Int Med Ctr Japan, Res Inst, Dept Intractable Dis, Shinuku Ku, Tokyo 1628655, Japan
来源：
CURRENT HIV RESEARCH | 2009年 / 7卷 / 02期
关键词：
HIV-1; Vpr; DNA double-strand breaks; ATM; homologous recombination; non-AIDS-defining cancers; HUMAN-IMMUNODEFICIENCY-VIRUS; CELL-CYCLE ARREST; TYPE-1; VPR; MICRONUCLEI FORMATION; UBIQUITIN LIGASE; ACCESSORY GENE; WEE-1; KINASE; CANCER-RISK; DAMAGE; PROTEIN;
D O I：
10.2174/157016209787581391
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We focus on the role of Vpr in inducing DNA double-strand breaks (DSBs) in the host cell. Based on the summarized findings of Vpr-induced DSBs and the finding of Vpr in the plasma of HIV-1-positive patients, we discuss the roles of Vpr in viral infection, especially viral infection of resting macrophages. We also describe the possible involvement of Vpr in non-AIDS-defining cancers, which represent an emerging crisis in HIV-1-positive patients.
引用
收藏
页码：109 / 113
页数：5
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