Bioactive secondary metabolites from the deep-sea derived fungus Aspergillus sp. SCSIO 41029

被引：10
|
作者：
Chen, Weihao [1 ,2 ]
Chen, Chunmei [1 ,2 ]
Long, Jieyi [1 ,2 ]
Lan, Sujuan [3 ]
Lin, Xiuping [1 ,4 ]
Liao, Shengrong [1 ,4 ]
Yang, Bin [1 ,4 ]
Zhou, Xuefeng [1 ,4 ]
Wang, Junfeng [1 ,4 ]
Liu, Yonghong [1 ,2 ,4 ]
机构：
[1] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecology, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol, Guangzhou 510301, Peoples R China
[2] Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
[3] Guangdong Pharmaceut Univ, Guangzhou 510006, Peoples R China
[4] Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Peoples R China
来源：
JOURNAL OF ANTIBIOTICS | 2021年 / 74卷 / 02期
基金：
中国国家自然科学基金;
关键词：
ENDOPHYTIC ASPERGILLUS; TERREUS; BUTYROLACTONES;
D O I：
10.1038/s41429-020-00378-y
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Two new compounds classified as one new lumazine peptide, penilumamide K (1) and one new sesquiterpene (2), were obtained from the deep-sea derived fungus Aspergillus sp. SCSIO 41029, together with eleven known compounds (3-13). The structures of 1-13 including absolute configurations were determined by detailed NMR spectroscopy, HR-ESI-MS, chemical derivatization, and optical rotation data. Among them, compound 1 represents the first lumazine peptide reported from deep-sea derived fungus. The bioactive assay exhibited that compounds 1, 3, 4, 5, 7 and 10 had significant potency against alpha-glucosidase with IC50 values ranging from 18.61 to 109.06 mu M. In addition, compounds 4 and 9 showed strong antibacterial activity against Staphylococcus aureus with MIC values of 0.78 and 6.25 mu g ml(-1), respectively.
引用
收藏
页码：156 / 159
页数：4
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