Bioactive secondary metabolites from the deep-sea derived fungus Aspergillus sp. SCSIO 41029

被引：11

作者：

Chen, Weihao ^{[1
,2
]}

Chen, Chunmei ^{[1
,2
]}

Long, Jieyi ^{[1
,2
]}

Lan, Sujuan ^{[3
]}

Lin, Xiuping ^{[1
,4
]}

Liao, Shengrong ^{[1
,4
]}

Yang, Bin ^{[1
,4
]}

Zhou, Xuefeng ^{[1
,4
]}

Wang, Junfeng ^{[1
,4
]}

Liu, Yonghong ^{[1
,2
,4
]}

机构：

[1] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecology, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol, Guangzhou 510301, Peoples R China

[2] Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China

[3] Guangdong Pharmaceut Univ, Guangzhou 510006, Peoples R China

[4] Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Peoples R China

来源：

JOURNAL OF ANTIBIOTICS | 2021年 / 74卷 / 02期

基金：

中国国家自然科学基金;

关键词：

ENDOPHYTIC ASPERGILLUS; TERREUS; BUTYROLACTONES;

D O I：

10.1038/s41429-020-00378-y

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two new compounds classified as one new lumazine peptide, penilumamide K (1) and one new sesquiterpene (2), were obtained from the deep-sea derived fungus Aspergillus sp. SCSIO 41029, together with eleven known compounds (3-13). The structures of 1-13 including absolute configurations were determined by detailed NMR spectroscopy, HR-ESI-MS, chemical derivatization, and optical rotation data. Among them, compound 1 represents the first lumazine peptide reported from deep-sea derived fungus. The bioactive assay exhibited that compounds 1, 3, 4, 5, 7 and 10 had significant potency against alpha-glucosidase with IC50 values ranging from 18.61 to 109.06 mu M. In addition, compounds 4 and 9 showed strong antibacterial activity against Staphylococcus aureus with MIC values of 0.78 and 6.25 mu g ml(-1), respectively.

引用

页码：156 / 159

页数：4

共 13 条

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