Palladium-catalyzed alkenation of thiophenes and furans by regioselective C-H bond functionalization

被引：42

作者：

Zhao, Jinlong ^{[1
]}

Huang, Lehao ^{[1
]}

Cheng, Kai ^{[1
]}

Zhang, Yuhong ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 23期

关键词：

Palladium; Heterocycles; Thiophene; Alkenation; C-H activation; HECK REACTION; ARYL CHLORIDES; OLEFINATION; ARYLATION; ALKENYLATION; ACTIVATION; VINYLATION; ALDEHYDES; BENZENES; LIGANDS;

D O I：

10.1016/j.tetlet.2009.03.124

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed direct alkenation of thiophenes and furans has been developed in the presence of AgOAc and pyridine. A variety of olefinic substrates such as acrylates, acrylamides, and acrylonitrile can perform the direct oxidative coupling reactions with various thiophenes and furans to give the mono-alkenylated products in good yields. In most cases, the (E)-isomers were isolated as the major products. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2758 / 2761

页数：4

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