Chemistry-based studies on oxidative DNA damage: Formation, repair, and mutagenesis

被引：147

作者：

Kasai, H ^{[1
]}

机构：

[1] Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, Dept Environm Oncol, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2002年 / 33卷 / 04期

关键词：

free radicals; 8-hydroxy-dG; 2-hydroxy-dATP; MTH1;

D O I：

10.1016/S0891-5849(02)00818-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since the discovery of 8-OH-dG formation, various aspects of oxidative DNA damage have been studied. For example, 2-OH-dA and a glyoxal-dG adduct were discovered as new types of oxidative DNA damage; 2-OH-dATP was found to induce mutations and to be a good substrate of a nucleotide sanitization enzyme, the MTHI protein; and efforts were continued to establish standard methodologies for 8-OH-dG analyses in urine and cellular DNA. By these studies, we found solid chemistry-based approaches were often useful to clarify the biological phenomena. (C) 2002 Elsevier Science Inc.

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页码：450 / 456

页数：7

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