New Prognostic Biomarkers in Metastatic Castration-Resistant Prostate Cancer

被引：41

作者：

Conteduca, Vincenza ^{[1
]}

Mosca, Alessandra ^{[2
]}

Brighi, Nicole ^{[1
]}

de Giorgi, Ugo ^{[1
]}

Rescigno, Pasquale ^{[3
]}

机构：

[1] Ist Sci Romagnolo Studio Cura Tumori IRST, Dept Med Oncol, IRCCS, I-47014 Meldola, Italy

[2] FPO IRCCS, Candiolo Canc Inst, Multidisciplinary Outpatient Oncol Clin, I-10060 Turin, Italy

[3] FPO IRCCS, Candiolo Canc Inst, Interdisciplinary Grp Translat Res & Clin Trials, Urol Canc GIRT Uro, I-10060 Turin, Italy

来源：

CELLS | 2021年 / 10卷 / 01期

关键词：

prostate cancer; androgen receptor; PTEN; DNA repair defects; prognostic biomarkers; ANDROGEN RECEPTOR; DNA-REPAIR; INCREASED SURVIVAL; ENZALUTAMIDE; ABIRATERONE; MUTATIONS; PTEN; MEN; EXPRESSION; LETHAL;

D O I：

10.3390/cells10010193

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Prostate cancer is one of the most frequent cancers in men and is a common cause of cancer-related death. Despite significant progress in the diagnosis and treatment of this tumor, patients who relapse after radical treatments inevitably develop metastatic disease. Patient stratification is therefore key in this type of cancer, and there is an urgent need for prognostic biomarkers that can define patients' risk of cancer-related death. In the last 10 years, multiple prognostic factors have been identified and studied. Here, we review the literature available and discuss the most common aberrant genomic pathways in metastatic castration-resistant prostate cancer shown to have a prognostic relevance in this setting.

引用

页码：1 / 13

页数：13

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