Preparation and Optimization of Curcumin-Hydroxy Propyl β Cyclodextrin Bioadhesive Vaginal Films for Human Papilloma Virus-Induced Cervical Cancer

Human Papilloma Virus (HPV) infections are the major cause of cervical cancers. To achieve a better therapeutic efficacy and patient compliance a novel bioadhesive vaginal film is formulated containing an anticancer drug curcunnin. The earlier developed Curcumin-Hydroxypropyl beta Cyclodextrin (HP beta CD) complex was employed in the present study to prepare polymeric film by solvent evaporation method using HPMC E15 and Carbopol 934P and characterized for physical, mechanical, and aesthetic properties. 3(2) factorial design was employed and found the effect on dependent variables like % elongation, Tensile strength, bioadhesion and % drug release. FT-IR spectra and DSC thermogram reveal that there was no chemical interaction between drug and excipients used. The mechanical properties, tensile strength, and percentage elongation at break reveal that the formulations were found to be soft and tough with good peelability. The film retained vaginal mucosa up to 6 h. The developed Curcumin-Hydroxypropyl beta Cyclodextrin Complex vaginal film could be a promising medication and can ensure longer residence at the vagina and provide an efficient therapy for HPV-induced cervical cancer.