Prevention Effects Moderate the Association of 5-HTTLPR and Youth Risk Behavior Initiation: Gene x Environment Hypotheses Tested via a Randomized Prevention Design

被引：130
作者：
Brody, Gene H. [1 ]
Beach, Steven R. H.
Philibert, Robert A. [2 ]
Chen, Yi-fu
Murry, Velma McBride
机构：
[1] Univ Georgia, Ctr Family Res, Athens, GA 30602 USA
[2] Univ Iowa, Iowa City, IA 52242 USA
来源：
CHILD DEVELOPMENT | 2009年 / 80卷 / 03期
关键词：
AFRICAN-AMERICAN FAMILIES; SEROTONIN TRANSPORTER GENE; STRESSFUL LIFE EVENTS; PROMOTER POLYMORPHISM; SUBSTANCE USE; NEIGHBORHOOD DISADVANTAGE; ALCOHOL-CONSUMPTION; RESEARCH STRATEGIES; SEXUAL-BEHAVIOR; SELF-CONTROL;
D O I：
10.1111/j.1467-8624.2009.01288.x
中图分类号：
G44 [教育心理学];
学科分类号：
0402 ; 040202 ;
摘要：
A randomized prevention design was used to investigate a moderation effect in the association between a polymorphism in the SCL6A4(5HTT) gene at 5-HTTLPR and increases in youths' risk behavior initiation. Participation in the Strong African American Families (SAAF) program was hypothesized to attenuate the link between 5-HTTLPR status and risk behavior initiation. Youths (N = 641, M age = 11.2 years) were assigned randomly to a SAAF or control condition. Risk behavior initiation across 29 months was linked positively with the 5-HTTLPR genotype and negatively with SAAF participation. Control youths at genetic risk initiated risk behavior at twice the rate of SAAF youths at genetic risk and youths not at genetic risk in either condition.
引用
收藏
页码：645 / 661
页数：17
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