Effective Immobilization of BMP-2 Mediated by Polydopamine Coating on Biodegradable Nanofibers for Enhanced in Vivo Bone Formation
被引:181
作者:
Cho, Hyeong-jin
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Hanyang Univ, Inst Bioengn & Biopharmaceut Res, Dept Bioengn, Seoul 133791, South KoreaHanyang Univ, Inst Bioengn & Biopharmaceut Res, Dept Bioengn, Seoul 133791, South Korea
Cho, Hyeong-jin
[1
]
Perikamana, Sajeesh Kumar Madhurakkat
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Hanyang Univ, Inst Bioengn & Biopharmaceut Res, Dept Bioengn, Seoul 133791, South KoreaHanyang Univ, Inst Bioengn & Biopharmaceut Res, Dept Bioengn, Seoul 133791, South Korea
Perikamana, Sajeesh Kumar Madhurakkat
[1
]
Lee, Ji-hye
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Hanyang Univ, Inst Bioengn & Biopharmaceut Res, Dept Bioengn, Seoul 133791, South KoreaHanyang Univ, Inst Bioengn & Biopharmaceut Res, Dept Bioengn, Seoul 133791, South Korea
Lee, Ji-hye
[1
]
Lee, Jinkyu
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Hanyang Univ, Inst Bioengn & Biopharmaceut Res, Dept Bioengn, Seoul 133791, South KoreaHanyang Univ, Inst Bioengn & Biopharmaceut Res, Dept Bioengn, Seoul 133791, South Korea
Lee, Jinkyu
[1
]
Lee, Kyung-Mi
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Korea Univ, Dept Biochem & Mol Biol, Global Res Lab, Coll Med, Seoul 136713, South KoreaHanyang Univ, Inst Bioengn & Biopharmaceut Res, Dept Bioengn, Seoul 133791, South Korea
Lee, Kyung-Mi
[2
]
Shin, Choongsoo S.
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Sogang Univ, Dept Mech Engn, Seoul 121742, South KoreaHanyang Univ, Inst Bioengn & Biopharmaceut Res, Dept Bioengn, Seoul 133791, South Korea
Shin, Choongsoo S.
[3
]
Shin, Heungsoo
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Hanyang Univ, Inst Bioengn & Biopharmaceut Res, Dept Bioengn, Seoul 133791, South KoreaHanyang Univ, Inst Bioengn & Biopharmaceut Res, Dept Bioengn, Seoul 133791, South Korea
Shin, Heungsoo
[1
]
机构:
[1] Hanyang Univ, Inst Bioengn & Biopharmaceut Res, Dept Bioengn, Seoul 133791, South Korea
[2] Korea Univ, Dept Biochem & Mol Biol, Global Res Lab, Coll Med, Seoul 136713, South Korea
[3] Sogang Univ, Dept Mech Engn, Seoul 121742, South Korea
Although bone morphogenic proteins (BMPs) have been widely used for bone regeneration, the ideal delivery system with optimized dose and minimized side effects is still active area of research. In this study, we developed bone morphogenetic protein-2(BMP-2) immobilized poly(L-lactide) (PLLA) nanofibers inspired by polydopamine, which could be ultimately used as membranes for guided bone regeneration, and investigated their effect on guidance of in vitro cell behavior and in vivo bone formation. Surface chemical analysis of the nanofibers confirmed successful immobilization of BMP-2 mediated by polydopamine, and about 9096 of BMP-2 was stably retained on the nanofiber surface for at least 28 days. The alkaline phosphatase activity and calcium mineralization of human mesenchymal stem cells (hMSCs) after 14 days of in vitro culture was significantly enhanced on nanofibers immobilized with BMP-2. More importantly, BMP-2 at a relatively small dose was highly active following implantation to the critical-sized defect in the cranium of mice; radiographic analysis demonstrated that 77.8 +/- 11.796 of newly formed bone was filled within the defect for a BMP-2-immobilized groups at the concentration of 124 +/- 9 ng/cm(2), as compared to 5.9 +/- 1.0 and 34.1 +/- 5.5% recovery, for a defect-only and a polydopamine-only group, respectively. Scanning and transmission electron microscopy of samples from the BMP-2 immobilized group showed fibroblasts and osteoblasts with nanofiber strands in the middle of regenerated bone tissue, revealing the importance of interaction between implanted nanofibers and the neighboring extracellular environment. Taken together, our data support that the presentation of BMP-2 on the surface of nanofibers as immobilized by utilizing polydopamine chemistry may be an effective method to direct bone growth at relatively low local concentration.
机构:
Technion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, Israel
Ben-David, Dror
;
Srouji, Samer
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Technion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, Israel
Srouji, Samer
;
Shapira-Schweitzer, Keren
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Technion Israel Inst Technol, Fac Biomed Engn, IL-32000 Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, Israel
Shapira-Schweitzer, Keren
;
Kossover, Olga
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机构:
Technion Israel Inst Technol, Fac Biomed Engn, IL-32000 Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, Israel
Kossover, Olga
;
Ivanir, Eran
论文数: 0引用数: 0
h-index: 0
机构:
Technion Israel Inst Technol, Fac Biomed Engn, IL-32000 Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, Israel
Ivanir, Eran
;
Kuhn, Gisela
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机构:
Swiss Fed Inst Technol, Inst Biomech, Zurich, SwitzerlandTechnion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, Israel
Kuhn, Gisela
;
Mueller, Ralph
论文数: 0引用数: 0
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机构:
Swiss Fed Inst Technol, Inst Biomech, Zurich, SwitzerlandTechnion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, Israel
Mueller, Ralph
;
Seliktar, Dror
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机构:
Technion Israel Inst Technol, Fac Biomed Engn, IL-32000 Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, Israel
Seliktar, Dror
;
Livne, Erella
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Technion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, Israel
机构:
Univ Roma Tor Vergata, Dept Ind Engn, Intrauniversitary Consortium Mat Sci & Technol IN, Res Unit Tor Vergata, Rome, ItalyUniv Roma Tor Vergata, Dept Ind Engn, Intrauniversitary Consortium Mat Sci & Technol IN, Res Unit Tor Vergata, Rome, Italy
Del Gaudio, Costantino
;
Baiguera, Silvia
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Adv Ctr Translat Regenerat Med ACTREM, SE-14186 Stockholm, SwedenUniv Roma Tor Vergata, Dept Ind Engn, Intrauniversitary Consortium Mat Sci & Technol IN, Res Unit Tor Vergata, Rome, Italy
Baiguera, Silvia
;
Boieri, Margherita
论文数: 0引用数: 0
h-index: 0
机构:
Univ Florence, Dept Clin & Expt Med, Florence, ItalyUniv Roma Tor Vergata, Dept Ind Engn, Intrauniversitary Consortium Mat Sci & Technol IN, Res Unit Tor Vergata, Rome, Italy
Boieri, Margherita
;
Mazzanti, Benedetta
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机构:
Univ Florence, Dept Clin & Expt Med, Florence, ItalyUniv Roma Tor Vergata, Dept Ind Engn, Intrauniversitary Consortium Mat Sci & Technol IN, Res Unit Tor Vergata, Rome, Italy
Mazzanti, Benedetta
;
Ribatti, Domenico
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机构:
Univ Bari, Unit Human Anat & Histol, Dept Basic Biomed Sci Neurosci & Sensory Organs, I-70121 Bari, Italy
Natl Canc Inst Giovanni Paolo II, Bari, ItalyUniv Roma Tor Vergata, Dept Ind Engn, Intrauniversitary Consortium Mat Sci & Technol IN, Res Unit Tor Vergata, Rome, Italy
Ribatti, Domenico
;
Bianco, Alessandra
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机构:
Univ Roma Tor Vergata, Dept Ind Engn, Intrauniversitary Consortium Mat Sci & Technol IN, Res Unit Tor Vergata, Rome, ItalyUniv Roma Tor Vergata, Dept Ind Engn, Intrauniversitary Consortium Mat Sci & Technol IN, Res Unit Tor Vergata, Rome, Italy
Bianco, Alessandra
;
Macchiarini, Paolo
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机构:
Karolinska Inst, Adv Ctr Translat Regenerat Med ACTREM, SE-14186 Stockholm, SwedenUniv Roma Tor Vergata, Dept Ind Engn, Intrauniversitary Consortium Mat Sci & Technol IN, Res Unit Tor Vergata, Rome, Italy
机构:
Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USAUniv Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
Jeong, Claire G.
;
Zhang, Huina
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Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USAUniv Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
Zhang, Huina
;
Hollister, Scott J.
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机构:
Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USAUniv Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
机构:
Korea Univ, Coll Med, Guro Hosp, Dept Orthoped Surg & Rare Dis, Seoul 152703, South KoreaKyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South Korea
Kim, Sung Eun
;
Song, Sang-Hun
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机构:
Kyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South KoreaKyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South Korea
Song, Sang-Hun
;
Yun, Young Pil
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机构:
Korea Univ, Coll Med, Guro Hosp, Dept Orthoped Surg & Rare Dis, Seoul 152703, South KoreaKyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South Korea
Yun, Young Pil
;
Choi, Byung-Joon
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机构:
Kyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South KoreaKyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South Korea
Choi, Byung-Joon
;
Kwon, Il Keun
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h-index: 0
机构:
Kyung Hee Univ, Sch Dent, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea
Kyung Hee Univ, Sch Dent, Inst Oral Biol, Seoul 130701, South KoreaKyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South Korea
Kwon, Il Keun
;
Bae, Min Soo
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机构:
Kyung Hee Univ, Sch Dent, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea
Kyung Hee Univ, Sch Dent, Inst Oral Biol, Seoul 130701, South KoreaKyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South Korea
Bae, Min Soo
;
Moon, Ho-Jin
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机构:
Kyung Hee Univ, Sch Dent, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea
Kyung Hee Univ, Sch Dent, Inst Oral Biol, Seoul 130701, South KoreaKyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South Korea
Moon, Ho-Jin
;
Kwon, Yong-Dae
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机构:
Kyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South KoreaKyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South Korea
机构:
Technion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, Israel
Ben-David, Dror
;
Srouji, Samer
论文数: 0引用数: 0
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机构:
Technion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, Israel
Srouji, Samer
;
Shapira-Schweitzer, Keren
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机构:
Technion Israel Inst Technol, Fac Biomed Engn, IL-32000 Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, Israel
Shapira-Schweitzer, Keren
;
Kossover, Olga
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h-index: 0
机构:
Technion Israel Inst Technol, Fac Biomed Engn, IL-32000 Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, Israel
Kossover, Olga
;
Ivanir, Eran
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机构:
Technion Israel Inst Technol, Fac Biomed Engn, IL-32000 Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, Israel
Ivanir, Eran
;
Kuhn, Gisela
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机构:
Swiss Fed Inst Technol, Inst Biomech, Zurich, SwitzerlandTechnion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, Israel
Kuhn, Gisela
;
Mueller, Ralph
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机构:
Swiss Fed Inst Technol, Inst Biomech, Zurich, SwitzerlandTechnion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, Israel
Mueller, Ralph
;
Seliktar, Dror
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机构:
Technion Israel Inst Technol, Fac Biomed Engn, IL-32000 Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, Israel
Seliktar, Dror
;
Livne, Erella
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机构:
Technion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Dept Anat & Cell Biol, IL-32000 Haifa, Israel
机构:
Univ Roma Tor Vergata, Dept Ind Engn, Intrauniversitary Consortium Mat Sci & Technol IN, Res Unit Tor Vergata, Rome, ItalyUniv Roma Tor Vergata, Dept Ind Engn, Intrauniversitary Consortium Mat Sci & Technol IN, Res Unit Tor Vergata, Rome, Italy
Del Gaudio, Costantino
;
Baiguera, Silvia
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Adv Ctr Translat Regenerat Med ACTREM, SE-14186 Stockholm, SwedenUniv Roma Tor Vergata, Dept Ind Engn, Intrauniversitary Consortium Mat Sci & Technol IN, Res Unit Tor Vergata, Rome, Italy
Baiguera, Silvia
;
Boieri, Margherita
论文数: 0引用数: 0
h-index: 0
机构:
Univ Florence, Dept Clin & Expt Med, Florence, ItalyUniv Roma Tor Vergata, Dept Ind Engn, Intrauniversitary Consortium Mat Sci & Technol IN, Res Unit Tor Vergata, Rome, Italy
Boieri, Margherita
;
Mazzanti, Benedetta
论文数: 0引用数: 0
h-index: 0
机构:
Univ Florence, Dept Clin & Expt Med, Florence, ItalyUniv Roma Tor Vergata, Dept Ind Engn, Intrauniversitary Consortium Mat Sci & Technol IN, Res Unit Tor Vergata, Rome, Italy
Mazzanti, Benedetta
;
Ribatti, Domenico
论文数: 0引用数: 0
h-index: 0
机构:
Univ Bari, Unit Human Anat & Histol, Dept Basic Biomed Sci Neurosci & Sensory Organs, I-70121 Bari, Italy
Natl Canc Inst Giovanni Paolo II, Bari, ItalyUniv Roma Tor Vergata, Dept Ind Engn, Intrauniversitary Consortium Mat Sci & Technol IN, Res Unit Tor Vergata, Rome, Italy
Ribatti, Domenico
;
Bianco, Alessandra
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma Tor Vergata, Dept Ind Engn, Intrauniversitary Consortium Mat Sci & Technol IN, Res Unit Tor Vergata, Rome, ItalyUniv Roma Tor Vergata, Dept Ind Engn, Intrauniversitary Consortium Mat Sci & Technol IN, Res Unit Tor Vergata, Rome, Italy
Bianco, Alessandra
;
Macchiarini, Paolo
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Adv Ctr Translat Regenerat Med ACTREM, SE-14186 Stockholm, SwedenUniv Roma Tor Vergata, Dept Ind Engn, Intrauniversitary Consortium Mat Sci & Technol IN, Res Unit Tor Vergata, Rome, Italy
机构:
Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USAUniv Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
Jeong, Claire G.
;
Zhang, Huina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USAUniv Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
Zhang, Huina
;
Hollister, Scott J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USAUniv Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
机构:
Korea Univ, Coll Med, Guro Hosp, Dept Orthoped Surg & Rare Dis, Seoul 152703, South KoreaKyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South Korea
Kim, Sung Eun
;
Song, Sang-Hun
论文数: 0引用数: 0
h-index: 0
机构:
Kyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South KoreaKyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South Korea
Song, Sang-Hun
;
Yun, Young Pil
论文数: 0引用数: 0
h-index: 0
机构:
Korea Univ, Coll Med, Guro Hosp, Dept Orthoped Surg & Rare Dis, Seoul 152703, South KoreaKyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South Korea
Yun, Young Pil
;
Choi, Byung-Joon
论文数: 0引用数: 0
h-index: 0
机构:
Kyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South KoreaKyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South Korea
Choi, Byung-Joon
;
Kwon, Il Keun
论文数: 0引用数: 0
h-index: 0
机构:
Kyung Hee Univ, Sch Dent, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea
Kyung Hee Univ, Sch Dent, Inst Oral Biol, Seoul 130701, South KoreaKyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South Korea
Kwon, Il Keun
;
Bae, Min Soo
论文数: 0引用数: 0
h-index: 0
机构:
Kyung Hee Univ, Sch Dent, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea
Kyung Hee Univ, Sch Dent, Inst Oral Biol, Seoul 130701, South KoreaKyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South Korea
Bae, Min Soo
;
Moon, Ho-Jin
论文数: 0引用数: 0
h-index: 0
机构:
Kyung Hee Univ, Sch Dent, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea
Kyung Hee Univ, Sch Dent, Inst Oral Biol, Seoul 130701, South KoreaKyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South Korea
Moon, Ho-Jin
;
Kwon, Yong-Dae
论文数: 0引用数: 0
h-index: 0
机构:
Kyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South KoreaKyung Hee Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Seoul 130701, South Korea