Cooperative Catalysis by Palladium and a Chiral Phosphoric Acid: Enantioselective Amination of Racemic Allylic Alcohols

被引：86

作者：

Banerjee, Debasis ^{[1
]}

Junge, Kathrin ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse, D-18059 Rostock, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 48期

关键词：

allylic alcohols; asymmetric amination; chiral phosphoric acids; palladium; phosphoramidite ligands; ASYMMETRIC ALPHA-ALLYLATION; BAYLIS-HILLMAN ADDUCTS; TERMINAL ALKYNES; BOND-CLEAVAGE; C-O; AMINES; ACTIVATION; EFFICIENT; SUBSTITUTION; ALKYLATION;

D O I：

10.1002/anie.201405511

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cooperative catalysis by [Pd(dba)(2)] and the chiral phosphoric acid BA1 in combination with the phosphoramidite ligand L8 enabled the efficient enantioselective amination of racemic allylic alcohols with a variety of functionalized amines. This catalytic protocol is highly regio- and stereo-selective (up to e.r. 96: 4) and furnishes valuable chiral amines in almost quantitative yield.

引用

页码：13049 / 13053

页数：5

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