Marizomib for central nervous system-multiple myeloma

被引：65

作者：

Badros, Ashraf ^{[1
]}

Singh, Zeba ^{[1
]}

Dhakal, Binod ^{[2
]}

Kwok, Young ^{[1
]}

MacLaren, Ann ^{[3
]}

Richardson, Paul ^{[4
]}

Trikha, Mohit ^{[3
]}

Hari, Parameswaran ^{[2
]}

机构：

[1] Univ Maryland, Med Ctr, M&S Greenebaum Canc Ctr, Baltimore, MD 21201 USA

[2] Med Coll Wisconsin, Div Hematol Oncol, Milwaukee, WI 53226 USA

[3] Triphase Accelerator, San Diego, CA USA

[4] Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2017年 / 177卷 / 02期

关键词：

multiple myeloma; central nervous system relapse; clinical studies; marizomib; INVOLVEMENT;

D O I：

10.1111/bjh.14498

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Marizomib, a natural marine product, is an irreversible proteasome inhibitor currently under investigation in relapsed-refractory multiple myeloma (RRMM) and malignant glioma. Central nervous system-multiple myeloma (CNS-MM) is a rare manifestation of extra-medullary disease with few therapeutic options, highlighting the unmet clinical need in these patients. Marizomib demonstrated encouraging activity in RRMM and has emerging clinical activity in glioma, making it a potential CNS-MM therapeutic intervention. Herein, we present two patients with RRMM and CNS involvement who benefited from marizomib-based therapy. Thesecases provide the first proof of principle for further exploring marizomib in CNS-MM patients.

引用

页码：221 / 225

页数：5

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