The targeting of non-coding RNAs by curcumin: Facts and hopes for cancer therapy

被引：51

作者：

Liu, Yun ^{[1
,2
]}

Sun, Hongmei ^{[3
]}

Makabel, Bolat ^{[4
]}

Cui, Qingbin ^{[5
,6
]}

Li, Jiajun ^{[1
,2
]}

Su, Chaoyue ^{[1
,2
]}

Ashby, Charles R., Jr. ^{[5
]}

Chen, Zhesheng ^{[5
]}

Zhang, Jianye ^{[1
,2
]}

机构：

[1] Guangzhou Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab Mol Target & Clin Pharmaco, Guangzhou 511436, Guangdong, Peoples R China

[2] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China

[3] Infinitus China Co Ltd, Jiangmen 529156, Guangdong, Peoples R China

[4] Xinjiang Inst Mat Med, Urumqi 830004, Xinjiang, Peoples R China

[5] St Johns Univ, Coll Pharm & Hlth Sci, 8000 Utopia Pkwy, New York, NY 11439 USA

[6] Guangzhou Med Univ, Coll Publ Hlth, Guangzhou 511436, Guangdong, Peoples R China

来源：

ONCOLOGY REPORTS | 2019年 / 42卷 / 01期

基金：

中国国家自然科学基金;

关键词：

curcumin; natural product; food; diet; miRNA; lncRNA; cancer; epigenetic pharmacology; INHIBITS CELL-GROWTH; BREAST-CANCER; PROSTATE-CANCER; COLORECTAL-CANCER; DOWN-REGULATION; UP-REGULATION; NASOPHARYNGEAL CARCINOMA; IN-VITRO; SECONDARY METABOLITES; MITOCHONDRIAL PATHWAY;

D O I：

10.3892/or.2019.7148

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Curcumin [(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl) hepta-1,6-diene-3,5-dione] is a natural polyphenol that is derived from the turmeric plant (curcuma longa L.). Curcumin is widely used in food coloring, preservatives, and condiments. Curcumin possesses anti-tumor, anti-oxidative and anti-inflammatory efficacy, as well as other pharmacological effects. Emerging evidence indicates that curcumin alters microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in various types of cancers. Both miRNAs and lncRNAs are non-coding RNAs that can epigenetically modulate the expression of multiple genes via post-transcriptional regulation. In the present review, the interactions between curcumin and non-coding RNAs are summarized in numerous types of cancers, including lung, colorectal, prostate, breast, nasopharyngeal, pancreatic, blood, and ovarian cancer, and the vital non-coding RNAs and their downstream targets are described.

引用

页码：20 / 34

页数：15

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