Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?

被引:269
作者
Goerlach, Agnes [1 ,2 ]
Dimova, Elitsa Y. [3 ]
Petry, Andreas [1 ,2 ]
Martinez-Ruiz, Antonio [4 ]
Hernansanz-Agustin, Pablo [4 ,5 ]
Rolo, Anabela P. [6 ,7 ]
Palmeira, Carlos M. [6 ,7 ]
Kietzmann, Thomas [3 ]
机构
[1] Tech Univ Munich, German Heart Ctr Munich, Expt & Mol Pediat Cardiol, D-80290 Munich, Germany
[2] DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany
[3] Univ Oulu, Bioctr Oulu, Fac Biochem & Mol Med, FI-90220 Oulu, Finland
[4] Hosp Univ La Princesa, Inst Invest Sanitaria Princesa, Serv Immunol, Madrid, Spain
[5] Univ Autonoma Madrid, Fac Med, Dept Bioquim, Madrid, Spain
[6] Univ Coimbra, Dept Life Sci, P-3000 Coimbra, Portugal
[7] Univ Coimbra, Ctr Neurosci & Cell Biol, P-3000 Coimbra, Portugal
关键词
Free radicals; Diets; Oxygen; Metabolism; Diseases; Mitochondria; Hypoxia; Diabetes; Obesity; NF-KAPPA-B; INDUCIBLE FACTOR-I; PROTEIN-KINASE-C; MITOCHONDRIAL-DNA MUTATIONS; FATTY-ACID OXIDATION; INSULIN-RESISTANCE; NADPH-OXIDASE; CHOLINE-DEFICIENT; CANCER PREVENTION; SIGNALING PATHWAY;
D O I
10.1016/j.redox.2015.08.016
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Within the last twenty years the view on reactive oxygen species (ROS) has changed; they are no longer only considered to be harmful but also necessary for cellular communication and homeostasis in different organisms ranging from bacteria to mammals. In the latter, ROS were shown to modulate diverse physiological processes including the regulation of growth factor signaling, the hypoxic response, inflammation and the immune response. During the last 60-100 years the life style, at least in the Western world, has changed enormously. This became obvious with an increase in caloric intake, decreased energy expenditure as well as the appearance of alcoholism and smoking; These changes were shown to contribute to generation of ROS which are, at least in part, associated with the occurrence of several chronic diseases like adiposity, atherosclerosis, type II diabetes, and cancer. In this review we discuss aspects and problems on the role of intracellular ROS formation and nutrition with the link to diseases and their problematic therapeutical issues. (C) 2015 Published by Elsevier B.V.
引用
收藏
页码:372 / 385
页数:14
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