Precision medicine at Memorial Sloan Kettering Cancer Center: clinical next-generation sequencing enabling next-generation targeted therapy trials

被引:111
作者
Hyman, David M. [1 ,2 ]
Solit, David B. [1 ,2 ,3 ,4 ]
Arcilas, Maria E. [5 ]
Cheng, Donavan T. [5 ]
Sabbatini, Paul [1 ,2 ]
Baselga, Jose [1 ,2 ,3 ]
Berger, Michael F. [2 ,3 ,4 ]
Ladanyi, Marc [3 ,5 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY USA
[2] Weill Cornell Med Coll, New York, NY USA
[3] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USA
[4] Mem Sloan Kettering Canc Ctr, Ctr Mol Oncol, New York, NY USA
[5] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY USA
关键词
CHEMOTHERAPY; MUTATIONS; CRIZOTINIB; GENOMICS;
D O I
10.1016/j.drudis.2015.08.005
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Implementing a center-wide precision medicine strategy at a major cancer center is a true multidisciplinary effort and requires comprehensive alignment of a broad screening strategy with a clinical research enterprise that can use these data to accelerate development of new treatments. Here, we describe the genomic screening approach at Memorial Sloan Kettering Cancer Center, a hybridization capture-based next-generation sequencing clinical assay for solid tumor molecular oncology designated MSK-IMPACT, and how it enables and supports a large clinical trial portfolio enriched for multi-histology, biomarker-selected, 'basket' studies of targeted therapies.
引用
收藏
页码:1422 / 1428
页数:7
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