Precision medicine at Memorial Sloan Kettering Cancer Center: clinical next-generation sequencing enabling next-generation targeted therapy trials

被引：111

作者：

Hyman, David M. ^{[1
,2
]}

Solit, David B. ^{[1
,2
,3
,4
]}

Arcilas, Maria E. ^{[5
]}

Cheng, Donavan T. ^{[5
]}

Sabbatini, Paul ^{[1
,2
]}

Baselga, Jose ^{[1
,2
,3
]}

Berger, Michael F. ^{[2
,3
,4
]}

Ladanyi, Marc ^{[3
,5
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY USA

[2] Weill Cornell Med Coll, New York, NY USA

[3] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USA

[4] Mem Sloan Kettering Canc Ctr, Ctr Mol Oncol, New York, NY USA

[5] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY USA

来源：

DRUG DISCOVERY TODAY | 2015年 / 20卷 / 12期

关键词：

CHEMOTHERAPY; MUTATIONS; CRIZOTINIB; GENOMICS;

D O I：

10.1016/j.drudis.2015.08.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Implementing a center-wide precision medicine strategy at a major cancer center is a true multidisciplinary effort and requires comprehensive alignment of a broad screening strategy with a clinical research enterprise that can use these data to accelerate development of new treatments. Here, we describe the genomic screening approach at Memorial Sloan Kettering Cancer Center, a hybridization capture-based next-generation sequencing clinical assay for solid tumor molecular oncology designated MSK-IMPACT, and how it enables and supports a large clinical trial portfolio enriched for multi-histology, biomarker-selected, 'basket' studies of targeted therapies.

引用

页码：1422 / 1428

页数：7

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