Synthesis and Antibacterial Evaluation of Some Novel Imidazole and Benzimidazole Sulfonamides

被引：70

作者：

Al-Mohammed, Nassir N. ^{[1
]}

Alias, Yatimah ^{[1
]}

Abdullah, Zanariah ^{[1
,2
]}

Shakir, Raied M. ^{[1
]}

Taha, Ekhlass M. ^{[3
]}

Hamid, Aidil Abdul ^{[4
]}

机构：

[1] Univ Malaya, Dept Chem, Fac Sci, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Sect Cocurricular Courses External Fac Electives, Kuala Lumpur 50603, Malaysia

[3] Univ Baghdad, Collage Sci Women, Dept Chem, Baghdad 10071, Iraq

[4] Univ Kebangsaan Malaysia, Fac Sci & Technol, Sch Biosci & Biotechnol, Bangi 43600, Selangor, Malaysia

来源：

MOLECULES | 2013年 / 18卷 / 10期

关键词：

sulfonamide; 4-methylbenzenesulfonamide; 4-nitrobenzenesulfonamide; 4-methoxybenzenesulfonamide; imidazole; benzimidazole; antibacterial activity; BIOLOGICAL EVALUATION; DERIVATIVES; DESIGN; ANTICANCER; COPPER(II); NICKEL(II); SAR;

D O I：

10.3390/molecules181011978

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several new substituted sulfonamide compounds were synthesized and their structures were confirmed by H-1-NMR, C-13-NMR, FT-IR, and mass spectroscopy. The antibacterial activities of the synthesized compounds were screened against standard strains of six Gram positive and four Gram negative bacteria using the microbroth dilution assay. Most of the compounds studied showed promising activities against both types of bacteria.

引用

页码：11978 / 11995

页数：18

共 45 条

[1] Synthesis and biological evaluation of a 99mTc-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia [J].

Akurathi, Vamsidhar ;

Dubois, Ludwig ;

Lieuwes, Natasja G. ;

Chitneni, Satish K. ;

Cleynhens, Bernard J. ;

Vullo, Daniela ;

Supuran, Claudiu T. ;

Verbruggen, Alfons M. ;

Lambin, Philippe ;

Bormans, Guy M. .

NUCLEAR MEDICINE AND BIOLOGY, 2010, 37 (05) :557-564

[2] N,N '-{[Ethane-1,2-diylbis(oxy)]bis-(ethane-2,1-diyl)}bis(4-methylbenzene-sulfonamide) [J].

Al-Mohammed, Nassir N. ;

Alias, Yatimah ;

Abdullah, Zanariah ;

Khaledi, Hamid .

ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 :O1983-+

[3] 1-Tosyl-2-[(1-tosyl-1H-benzimidazol-2-yl)methylsulfanyl]-1H-benzimidazole [J].

Al-Mohammed, Nassir N. ;

Alias, Yatimah ;

Abdullah, Zanariah ;

Khaledi, Hamid .

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 :O1043-U1487

[4] Synthesis and Preliminary Antimicrobial Activities of New Arylideneamino-1,3,4-thiadiazole-(thio/dithio)-acetamido Cephalosporanic Acids [J].

Alwan, Shakir Mahmood .

MOLECULES, 2012, 17 (01) :1025-1038

[5] Synthesis, biological evaluation and SAR of sulfonamide 4-methoxychalcone derivatives with potential antileishmanial activity [J].

Andrighetti-Frohner, Carla R. ;

de Oliveira, Kely N. ;

Gaspar-Silva, Daniela ;

Pacheco, Leticia K. ;

Joussef, Antonio C. ;

Steindel, Mario ;

Simoes, Claudia M. O. ;

de Souza, Alessandra M. T. ;

Magalhaes, Uiaran O. ;

Afonso, Ilidio F. ;

Rodrigues, Carlos R. ;

Nunes, Ricardo J. ;

Castro, Helena C. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (02) :755-763

[6]

[Anonymous], 1963, The Proteins

[7]

[Anonymous], M7A7 CLIN LAB STAND

[8] Synthesis and Antibacterial Activities of New Metronidazole and Imidazole Derivatives [J].

Atia, Abdul Jabar Kh. .

MOLECULES, 2009, 14 (07) :2431-2446

[9] Synthesis and Antibacterial Evaluation of Novel Heterocyclic Compounds Containing a Sulfonamido Moiety [J].

Azab, Mohammad Emad ;

Youssef, Mohamed M. ;

El-Bordany, Eman A. .

MOLECULES, 2013, 18 (01) :832-844

[10] Synthesis and biological evaluation of some new 2-pyrazolines bearing benzene sulfonamide moiety as potential anti-inflammatory and anti-cancer agents [J].

Bano, Sameena ;

Javed, Kalim ;

Ahmad, Shamim ;

Rathish, I. G. ;

Singh, Surender ;

Alam, M. S. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (12) :5763-5768

← 1 2 3 4 5 →