Acetaldehyde at Clinically Relevant Concentrations Inhibits Inward Rectifier Potassium Current IK1 in Rat Ventricular Myocytes

被引：5

作者：

Bebarova, M. ^{[1
]}

Matejovic, P. ^{[1
]}

Simurdova, M. ^{[1
]}

Simurda, J. ^{[1
]}

机构：

[1] Masaryk Univ, Fac Med, Dept Physiol, Kamenice 5, Brno 62500, Czech Republic

来源：

PHYSIOLOGICAL RESEARCH | 2015年 / 64卷 / 06期

关键词：

Acetaldehyde; Arrhythmias; Inward rectifier; I-K1; inhibition; Rat ventricular myocytes; ETHANOL; HEART; CA2+;

D O I：

10.33549/physiolres.932985

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Considering the effects of alcohol on cardiac electrical behavior as well as the important role of the inward rectifier potassium current I-K1 in arrhythmogenesis, this study was aimed at the effect of acetaldehyde, the primary metabolite of ethanol, on IK1 in rat ventricular myocytes. Acetaldehyde induced a reversible inhibition of I-K1 with IC50 = 53.7 +/- 7.7 mu M at -110 mV; a significant inhibition was documented even at clinically-relevant concentrations ( at 3 mu M by 13.1 +/- 3.0 %). The inhibition was voltage-independent at physiological voltages above -90 mV. The I-K1 changes under acetaldehyde may contribute to alcohol-induced alterations of cardiac electrophysiology, especially in individuals with a genetic defect of aldehyde dehydrogenase where the acetaldehyde level may be elevated.

引用

页码：939 / 943

页数：5

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