Efficacy of β-lactams for treating experimentally induced pneumonia due to a carbapenem-hydrolyzing metallo-β-lactamase-producing strain of Pseudomonas aeruginosa

被引：34
作者：
Bellais, S
Mimoz, O
Léotard, S
Jacolot, A
Petitjean, O
Nordmann, P
机构：
[1] Hop Bicetre, Serv Bacteriol Virol Hyg, Assistance Publ Hop Paris, Fac Med Paris Sud, F-94275 Le Kremlin Bicetre, France
[2] Univ Miletrie, Ctr Hosp, Dept Anesthesie & Reanimat Chirurg, F-86021 Poitiers, France
[3] Fac Med Paris Nord, Ctr Rech & Pathol Infect & Trop, F-93009 Bobigny, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 06期
关键词：
D O I：
10.1128/AAC.46.6.2032-2034.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A rat pneumonia model was established with a Pseudomonas aeruginosa strain that produced the plasmid-encoded metallocarbapenemase VIM-2. A significant decrease in lung bacterial titers was observed Mien imipenem, cefepime, ceftazidime, and piperacillin-tazobactam were given at the highest doses recommended for humans, despite their high MICs. Aztreonam at high doses produced a similar decrease in bacterial titers.
引用
收藏
页码：2032 / 2034
页数：3
相关论文
共 50 条
  • [21] Occurrence of VIM-4 metallo-β-lactamase-producing Pseudomonas aeruginosa in an Algerian hospital
    Merradi, Manel
    Kassah-Laouar, Ahmed
    Ayachi, Ammar
    Heleili, Nouzha
    Menasria, Taha
    Hocquet, Didier
    Cholley, Pascal
    Sauget, Marlene
    [J]. JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 2019, 13 (04): : 284 - 290
  • [22] Evaluation of Phenotypic Tests for Detection of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa Strains in China
    Qu, Ting-ting
    Zhang, Jun-li
    Wang, Jie
    Tao, Jing
    Yu, Yun-song
    Chen, Ya-gang
    Zhou, Jian-ying
    Li, Lan-juan
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2009, 47 (04) : 1136 - 1142
  • [23] Molecular characterization of metallo-β-lactamase-producing Pseudomonas aeruginosa in a Czech hospital (2009-2011)
    Papagiannitsis, C. C.
    Studentova, V.
    Ruzicka, F.
    Tejkalova, R.
    Hrabak, J.
    [J]. JOURNAL OF MEDICAL MICROBIOLOGY, 2013, 62 : 945 - 947
  • [24] Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in Two Iranian Teaching Hospitals, Their Antimicrobial Susceptibility and Serotypes
    Yousefi, S.
    Nahaei, M. R.
    Farajnia, S.
    Akhi, M. T.
    Ghotaslou, R.
    Lotfipour, F.
    Soroush, M. H.
    [J]. JOURNAL OF CHEMOTHERAPY, 2011, 23 (02) : 114 - 116
  • [25] Evaluation of phenotypic tests for the detection of metallo-β-lactamase-producing Pseudomonas aeruginosa in a low prevalence country
    Samuelsen, Orjan
    Buaro, Liselotte
    Giske, Christian G.
    Simonsen, Gunnar S.
    Aasnaes, Bettina
    Sundsfjord, Arnfinn
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 61 (04) : 827 - 830
  • [26] SPM-1 metallo-β-lactamase-producing Pseudomonas aeruginosa ST277 in the UK
    Hopkins, Katie L.
    Meunier, Daniele
    Findlay, Jacqueline
    Mustafa, Nazim
    Parsons, Helena
    Pike, Rachel
    Wright, Laura
    Woodford, Neil
    [J]. JOURNAL OF MEDICAL MICROBIOLOGY, 2016, 65 : 696 - 697
  • [27] Molecular Epidemiology and Clinical Implications of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa Isolated from Urine
    Sako, Shinichi
    Kariyama, Reiko
    Mitsuhata, Ritsuko
    Yamamoto, Masumi
    Wada, Koichiro
    Ishii, Ayano
    Uehara, Shinya
    Kokeguchi, Susumu
    Kusano, Nobuchika
    Kumon, Hiromi
    [J]. ACTA MEDICA OKAYAMA, 2014, 68 (02) : 89 - 99
  • [28] VIM-2 metallo-β-lactamase-producing Pseudomonas aeruginosa causing an outbreak in South Africa
    Jacobson, Rachael Kiera
    Minenza, Nadia
    Nicol, Mark
    Bamford, Colleen
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2012, 67 (07) : 1797 - 1798
  • [29] Multiyear, Multinational Survey of the Incidence and Global Distribution of Metallo-β-Lactamase-Producing Enterobacteriaceae and Pseudomonas aeruginosa
    Kazmierczak, Krystyna M.
    Rabine, Sharon
    Hackel, Meredith
    McLaughlin, Robert E.
    Biedenbach, Douglas J.
    Bouchillon, Samuel K.
    Sahm, Daniel F.
    Bradford, Patricia A.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 60 (02) : 1067 - 1078
  • [30] In Vitro Potentiation of Carbapenems with ME1071, a Novel Metallo-β-Lactamase Inhibitor, against Metallo-β-Lactamase-Producing Pseudomonas aeruginosa Clinical Isolates
    Ishii, Yoshikazu
    Eto, Maki
    Mano, Yoko
    Tateda, Kazuhiro
    Yamaguchi, Keizo
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (09) : 3625 - 3629
12345