Efficacy of β-lactams for treating experimentally induced pneumonia due to a carbapenem-hydrolyzing metallo-β-lactamase-producing strain of Pseudomonas aeruginosa

被引：34
|
作者：
Bellais, S
Mimoz, O
Léotard, S
Jacolot, A
Petitjean, O
Nordmann, P
机构：
[1] Hop Bicetre, Serv Bacteriol Virol Hyg, Assistance Publ Hop Paris, Fac Med Paris Sud, F-94275 Le Kremlin Bicetre, France
[2] Univ Miletrie, Ctr Hosp, Dept Anesthesie & Reanimat Chirurg, F-86021 Poitiers, France
[3] Fac Med Paris Nord, Ctr Rech & Pathol Infect & Trop, F-93009 Bobigny, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 06期
关键词：
D O I：
10.1128/AAC.46.6.2032-2034.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A rat pneumonia model was established with a Pseudomonas aeruginosa strain that produced the plasmid-encoded metallocarbapenemase VIM-2. A significant decrease in lung bacterial titers was observed Mien imipenem, cefepime, ceftazidime, and piperacillin-tazobactam were given at the highest doses recommended for humans, despite their high MICs. Aztreonam at high doses produced a similar decrease in bacterial titers.
引用
收藏
页码：2032 / 2034
页数：3
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