Heterogeneity and hierarchy of hematopoietic stem cells

被引:99
作者
Ema, Hideo [1 ]
Morita, Yohei [2 ]
Suda, Toshio [1 ]
机构
[1] Keio Univ, Sch Med, Sakaguchi Lab Dev Biol, Dept Cell Differentiat, Tokyo 1608582, Japan
[2] Fritz Lipmann Inst, Leibnitz Inst Age Res, Jenna, Germany
关键词
SELF-RENEWAL CAPACITY; IN-VIVO PROLIFERATION; MURINE FETAL LIVER; LINEAGE COMMITMENT; COMPETITIVE REPOPULATION; MYELOID LINEAGES; CLONAL ANALYSIS; EARLIEST STAGE; B-CELL; PROGENITORS;
D O I
10.1016/j.exphem.2013.11.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hematopoietic stem cells (HSCs) are a more heterogeneous population than previously thought. Extensive analysis of reconstitution kinetics after transplantation allows a new classifications of HSCs based on lineage balance. Previously unrecognized classes of HSCs, such as myeloid- and lymphoid-biased HSCs, have emerged. However, varying nomenclature has been used to describe these cells, promoting confusion in the field. To establish a common nomenclature, we propose a reclassification of short-, intermediate-, and long-term (ST, IT, and LT) HSCs defined as: ST < 6 months, IT > 6 months, and LT > 12. We observe that myeloid-biased HSCs or alpha cells overlap with LT-HSCs, whereas lymphoid-biased HSCs or gamma/delta cells overlap with ST-HSCs, suggesting that HSC lifespan is linked to cell differentiation. We also suggest that HSC heterogeneity prompts reconsideration of long-term ( > 4 months) multilineage reconstitution as the gold standard for HSC detection. In this review, we discuss relationships among ST-, IT-, and LT-HSCs relevant to stem cell heterogeneity, hierarchical organization, and differentiation pathways. (C) 2014 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc.
引用
收藏
页码:74 / 82
页数:9
相关论文
共 63 条
[1]   Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential:: A revised road map for adult blood lineage commitment [J].
Adolfsson, J ;
Månsson, R ;
Buza-Vidas, N ;
Hultquist, A ;
Liuba, K ;
Jensen, CT ;
Bryder, D ;
Yang, LP ;
Borge, OJ ;
Thoren, LAM ;
Anderson, K ;
Sitnicka, E ;
Sasaki, Y ;
Sigvardsson, M ;
Jacobsen, SEW .
CELL, 2005, 121 (02) :295-306
[2]   A clonogenic common myeloid progenitor that gives rise to all myeloid lineages [J].
Akashi, K ;
Traver, D ;
Miyamoto, T ;
Weissman, IL .
NATURE, 2000, 404 (6774) :193-197
[3]   Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages [J].
Arinobu, Yojiro ;
Mizuno, Shin-ichi ;
Chong, Yong ;
Shigematsu, Hirokazu ;
Lino, Tadafumi ;
Iwasaki, Hiromi ;
Graf, Thomas ;
Mayfield, Robin ;
Chan, Susan ;
Kastner, Philippe ;
Akashi, Koichi .
CELL STEM CELL, 2007, 1 (04) :416-427
[4]   Intermediate-Term Hematopoietic Stem Cells with Extended but Time-Limited Reconstitution Potential [J].
Benveniste, Patricia ;
Frelin, Catherine ;
Janmohamed, Salima ;
Barbara, Mary ;
Herrington, Robert ;
Hyam, Deborah ;
Iscove, Norman N. .
CELL STEM CELL, 2010, 6 (01) :48-58
[5]   The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development [J].
Benz, Claudia ;
Martins, Vera C. ;
Radtke, Freddy ;
Bleul, Conrad C. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (05) :1187-1199
[6]   Hematopoietic Stem Cell Subtypes Expand Differentially during Development and Display Distinct Lymphopoietic Programs [J].
Benz, Claudia ;
Copley, Michael R. ;
Kent, David G. ;
Wohrer, Stefan ;
Cortes, Adrian ;
Aghaeepour, Nima ;
Ma, Elaine ;
Mader, Heidi ;
Rowe, Keegan ;
Day, Christopher ;
Treloar, David ;
Brinkman, Ryan R. ;
Eaves, Connie J. .
CELL STEM CELL, 2012, 10 (03) :273-283
[7]   Commitment and developmental potential of extrathymic and intrathymic T cell precursors:: Plenty to choose from [J].
Bhandoola, Avinash ;
von Boehmer, Harald ;
Petrie, Howard T. ;
Zuniga-Pfluecker, Juan Carlos .
IMMUNITY, 2007, 26 (06) :678-689
[8]   All Hematopoietic Cells Develop from Hematopoietic Stem Cells through Flk2/Flt3-Positive Progenitor Cells [J].
Boyer, Scott W. ;
Schroeder, Aaron V. ;
Smith-Berdan, Stephanie ;
Forsberg, E. Camilla .
CELL STEM CELL, 2011, 9 (01) :64-73
[9]  
Bradford GB, 1997, EXP HEMATOL, V25, P445
[10]   Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-β1 [J].
Challen, Grant A. ;
Boles, Nathan C. ;
Chambers, Stuart M. ;
Goodell, Margaret A. .
CELL STEM CELL, 2010, 6 (03) :265-278