Merging Gold and Organocatalysis: A Facile Asymmetric Synthesis of Annulated Pyrroles

被引：25

作者：

Hack, Daniel ^{[1
]}

Loh, Charles C. J. ^{[1
]}

Hartmann, Jan M. ^{[1
]}

Raabe, Gerhard ^{[1
]}

Enders, Dieter ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 14期

基金：

欧洲研究理事会;

关键词：

annulation; gold catalysis; organocatalysis; primary-amine catalysis; pyrroles; FRIEDEL-CRAFTS ALKYLATION; ENANTIOSELECTIVE SYNTHESIS; CATALYZED REACTIONS; HYDROARYLATION; ALDEHYDES; ENONES; FUNCTIONALIZATION; CARBOCYCLIZATION; HYDROGENATION; REACTIVITY;

D O I：

10.1002/chem.201400407

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The combination of cinchona-alkaloid-derived primary amine and Au-I-phosphine catalysts allowed the selective CH functionalization of two adjacent carbon atoms of pyrroles under mild reaction conditions. This sequential dual activation provides seven-membered-ring-annulated pyrrole derivatives in excellent yields and enantioselectivities.

引用

页码：3917 / 3921

页数：5

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