γ-Mangostin from Garcinia Mangostana Pericarps as a Dual Agonist That Activates Both PPARα and PPARδ

被引：25

作者：

Matsuura, Nobuyasu ^{[1
]}

Gamo, Kanae ^{[1
,2
]}

Miyachi, Hiroyuki ^{[2
]}

Iinuma, Munekazu ^{[3
]}

Kawada, Teruo ^{[4
]}

Takahashi, Nobuyuki ^{[4
]}

Akao, Yukihiro ^{[5
]}

Tosa, Hideki ^{[6
]}

机构：

[1] Okayama Univ Sci, Fac Sci, Dept Life Sci, Kita Ku, Okayama 7000005, Japan

[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pharmaceut Sci, Kita Ku, Okayama 7008530, Japan

[3] Gifu Pharmaceut Univ, Fac Pharmaceut Sci, Gifu 5011196, Japan

[4] Kyoto Univ, Grad Sch Agr, Div Food Sci & Biotechnol, Uji, Kyoto 6110011, Japan

[5] Gifu Univ, United Grad Sch Drug Discovery & Med Informat Sci, Gifu 5011193, Japan

[6] Field & Device Co, Osaka 5410045, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2013年 / 77卷 / 12期

关键词：

dual agonist; Garcinia mangostana pericarp; PPAR alpha; PPAR delta; gamma-mangostin; LIPID-METABOLISM; GENE-EXPRESSION; 2; XANTHONES; ROOT BARK;

D O I：

10.1271/bbb.130541

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We tested the peroxisome proliferator-activated receptor (PPAR)delta agonistic activity of a Garcinia mangostana pericarp extract to develop a treatment for the metabolic syndrome, and demonstrated gamma-mangostin to be an active compound on the basis of a luciferase reporter gene assay. gamma-Mangostin induced the expression of the uncoupling protein-3 (UCP-3) gene which is related to energy expenditure and fat metabolism in L6 cells. We showed that gamma-mangostin is a dual agonist that activates both PPAR delta and PPAR alpha. gamma-Mangostin also induced the expression of acyl-CoA synthase and carnitine palmitoyl-transferase 1A genes in HepG2 cells. These results suggest the potential of gamma-mangostin as a preventive agent of the metabolic syndrome.

引用

页码：2430 / 2435

页数：6

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