Atopic Dermatitis and the Role of the Skin Microbiome in Choosing Prevention, Treatment, and Maintenance Options

被引：0

作者：

Baldwin, Hilary ^{[1
]}

Aguh, Crystal ^{[2
]}

Andriessen, Anneke ^{[3
,4
]}

Benjamin, Latanya ^{[5
]}

Ferberg, Aaron S. ^{[6
,7
]}

Hooper, Deirdre ^{[8
,9
,10
]}

Jarizzo, Joseph L. ^{[11
,12
]}

Lio, Peter A. ^{[13
,14
]}

Tlougan, Brook ^{[15
,16
]}

Woolery-Lloyd, Heather C. ^{[17
]}

Zeichner, Joshua ^{[7
,18
]}

机构：

[1] Acne Treatment & Res Ctr, Brooklyn, NY USA

[2] Johns Hopkins Univ, Sch Med, Dept Dermatol, Ethn Skin Program, Baltimore, MD 21205 USA

[3] Radboud Univ Nijmegen, Med Ctr, Nijmegen, Netherlands

[4] Andriessen Consultants, Malden, Netherlands

[5] Florida Atlantic Univ, Boca Raton, FL 33431 USA

[6] Arkansas Res Trials, Arkansas Dermatol Skin Canc Ctr, Little Rock, AR USA

[7] Icahn Sch Med Mt Sinai, Dept Dermatol, New York, NY 10029 USA

[8] Audubon Dermatol, New Orleans, LA USA

[9] Tulane Univ, New Orleans, LA 70118 USA

[10] Louisiana State Univ, New Orleans, LA USA

[11] Wake Forest Sch Med, Winston Salem, NC 27101 USA

[12] Weill Cornell Med Coll, New York, NY USA

[13] Northwestern Univ, Dept Dermatol, Feinberg Sch Med, Chicago, IL 60611 USA

[14] Med Dermatol Associates Chicago, Chicago, IL USA

[15] Westmed Med Grp, Purchase, NY USA

[16] Columbia Univ, Irving Med Ctr, New York, NY USA

[17] Miller Univ Miami, Sch Med, Frost Dept Dermatol & Cutaneous Surg, Miami, FL USA

[18] Mt Sinai Hosp, Dept Dermatol, New York, NY 10029 USA

来源：

JOURNAL OF DRUGS IN DERMATOLOGY | 2020年 / 19卷 / 10期

关键词：

TOPICAL CALCINEURIN INHIBITORS; EPIDERMAL BARRIER DYSFUNCTION; SYSTEMATIC ANALYSIS; ECZEMA PREVALENCE; GLOBAL BURDEN; CHILDREN; DISEASE; EPIDEMIOLOGY; COMMUNITY; INJURIES;

D O I：

10.36849/JDD.2020.5393

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Atopic dermatitis (AD) is a common skin condition characterized by disturbed barrier function, skin inflammation, and cutaneous dysbiosis. Clinically, it manifests as chronic-recurrent xerosis, pruritus, and erythematous lesions. Its pathophysiology is complex, making the selection of appropriate treatment options a task. Aim: To share insights gained from a literature review and discussions with experts in dermatology on key factors related to the prevention, treatment, and management of AD in relation to the skin microbiome. Methods: Results from an expert panel were summarized and discussed to provide updated recommendations for the treatment and maintenance of AD. Results: Evidence supports a strategy for managing inflammatory skin diseases with a selenium-rich post-biotic thermal water and biomass containing moisturizer. The moisturizer helps to restore homeostasis of the skin, re-populate a diverse microbiome, encourage the growth of commensal bacteria, and improve barrier function and symptoms of AD. Conclusions: Normalization of skin microbiome diversity using a topical moisturizer containing post-biotic aqua and biomass may offer a valuable option for the treatment and maintenance of inflammatory skin diseases. Clinicians should discuss the benefits of this treatment in the context of a full AD management program that covers prevention, active treatment, and maintenance.

引用

页码：935 / 940

页数：6

共 56 条

[21] Atopic dermatitis [J].