Effect of aging and hormonal replacement therapy on rat testes: Links with apoptosis, mitochondrial function and oxidative stress

被引：0
作者：
Nassar, S [1 ]
El-Ashmawy, N [1 ]
El-Sawy, S [1 ]
Attia, M [1 ]
El-Hassaneen, Y [1 ]
机构：
[1] Tanta Univ, Dept Dermatol, Fac Med, Tanta, Egypt
来源：
ANDROLOGY IN THE 21ST CENTURY, SHORT COMMUNICATIONS | 2001年
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D O I：
暂无
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
This study was designed to investigate the mechanisms underlying age related decline in spermatogenesis. Four groups (Gp) of rats of 6,12,16&26 mo old were included. GpIII was subdivided into a,b & c. s.c. testosterone (T) and oral vit E were given for Gp III a & b,respectively. PlasmaT, bioactiveT, LH and FSH were measured. Apoptosis of the testes was detected by TUNEL and E.M. Testicular telomerase activity, GSSG/GSH, cytochrome c oxidase & 8-OHdG were estimated. The results showed rat aging began at 16 mo old & manifested by decrease in bioactive T, free T and LH, whereas FSH increased. Apoptotic index increase & mitochondrial changes of Leydig cells started at 16 mo. The concomitant decrease of mitochondrial CCO & increase in GSSG/GSH support the mitochondrial role in age related germ cell loss via apoptosis. The slight improvement of these parameters in groups IIIa&b indicate that endocrine aging in males is inevitable.
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页码：733 / 738
页数：4
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