In vivo Elimination of Clonidine by Continuous Venovenous Hemofiltration in Critically Ill Patients

被引：1

作者：

van den Oever, Huub L. A. ^{[1
]}

Zeeman, Marieke ^{[2
]}

Nassikovker, Polina ^{[1
]}

Bles, Carmen ^{[1
]}

van Steveninck, Fred A. L. ^{[1
]}

de Meijer, Arthur R. ^{[1
]}

Kruisdijk-Gerritsen, Arriette ^{[1
]}

Arbouw, Maurits ^{[3
]}

机构：

[1] Deventer Hosp, Intens Care Unit, Nico Bolkesteinlaan 75, NL-7416 SE Deventer, Netherlands

[2] Deventer Hosp, Dept Clin Geriatr, Deventer, Netherlands

[3] Deventer Hosp, Dept Clin Pharm, Deventer, Netherlands

来源：

BLOOD PURIFICATION | 2020年 / 49卷 / 05期

关键词：

Clonidine; Continuous venovenous hemofiltration; Hemofiltration; Sieving coefficient; Critical illness; PHARMACOKINETICS;

D O I：

10.1159/000505610

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background:Clonidine is an alpha(2)-agonist that is commonly used for sedation in the intensive care unit. When patients are on continuous venovenous hemofiltration (CVVH) in the presence of kidney dysfunction, the sieving coefficient of clonidine is required to estimate how much drug is removed by CVVH. In the present study, we measured the sieving coefficient of clonidine in critically ill, ventilated patients receiving CVVH.Methods:A total of 20 samples of plasma and ultrafiltrate of 3 patients on CVVH, using a standard 1.5 m(2) polyacrylonitrile AN69 membrane, during continuous clonidine infusion were collected. After correction for the effect of predilution, we calculated the sieving coefficient for clonidine.Results:The mean sieving coefficient of clonidine was 0.52 (SD 0.097).Conclusion:Using a polyacrylonitrile AN69 membrane in a CVVH machine, the in vivo sieving coefficient of clonidine was 0.52.

引用

页码：622 / 626

页数：5

共 15 条

[1]

[Anonymous], PUBCHEM DAT

[2] NEW ASPECTS OF THE PHARMACOKINETICS AND PHARMACODYNAMICS OF CLONIDINE IN MAN [J].

ARNDTS, D ;

DOEVENDANS, J ;

KIRSTEN, R ;

HEINTZ, B .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 24 (01) :21-30

[3]

Assadi Farahnak, 2016, Front Biosci (Schol Ed), V8, P56

[4]

Bailie GR, 2013, 2013 DIALYSIS DRUGS

[5]

DAVIES DS, 1977, CLIN PHARMACOL THER, V21, P593

[6] Sedative, analgesic and cognitive effects of clonidine infusions in humans [J].

Hall, JE ;

Uhrich, TD ;

Ebert, TJ .

BRITISH JOURNAL OF ANAESTHESIA, 2001, 86 (01) :5-11

[7] In vitro and in vivo evaluation of enoxaparin removal by continuous renal replacement therapies with acrylonitrile and polysulfone membranes [J].

Isla, A ;

Gascón, AR ;

Maynar, J ;

Arzuaga, A ;

Corral, E ;

Martín, A ;

Solinís, MA ;

Muñoz, JLP .

CLINICAL THERAPEUTICS, 2005, 27 (09) :1444-1451

[8] CLONIDINE AND THE KIDNEY [J].

ITSKOVITZ, HD .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1980, 2 :S47-S60

[9]

Kellum JA, 2012, CLIN PRACTICE GUIDEL

[10] Population pharmacokinetics of intravenous clonidine for sedation during paediatric extracorporeal membrane oxygenation and continuous venovenous hemofiltration [J].

Kleiber, Niina ;

Mathot, Ron A. A. ;

Ahsman, Maurice J. ;

Wildschut, Enno D. ;

Tibboel, Dick ;

de Wildt, Saskia N. .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2017, 83 (06) :1227-1239

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