Rho-directed forces in collective migration

被引：38

作者：

Friedl, Peter ^{[1
]}

Wolf, Katarina ^{[2
]}

Zegers, Mirjam M. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Cell Biol, NL-6500 HB Nijmegen, Netherlands

[2] Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, David H Koch Ctr Appl Res Genitourinary Canc, Houston, TX USA

来源：

NATURE CELL BIOLOGY | 2014年 / 16卷 / 03期

关键词：

CELL-MOVEMENT; ACTIVATION; CONTRACTILITY; PLASTICITY; POLARITY; RAC;

D O I：

10.1038/ncb2923

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Collective cell migration depends on multicellular mechanocoupling between leader and follower cells to coordinate traction force and position change. Co-registration of Rho GTPase activity and forces in migrating epithelial cell sheets now shows how RhoA controls leader-follower cell hierarchy, multicellular cytoskeletal contractility and mechanocoupling, to prevent ectopic leading edges and to move the cell sheet forward.

引用

页码：208 / 210

页数：3

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