Wavefront aberrations measured with Hartmann-Shack sensor in patients with keratoconus

Objective: To compare the ocular wavefront aberrations of normal and keratoconic eyes and to describe the characteristics of the higher-order aberrations in eyes with keratoconus. Design: Prospective case control and observational study. Participants: Thirty-five keratoconic eyes and thirty-eight normal controls. Methods: Higher-order aberrations in refraction were measured with a wavefront sensor, and those aberrations resulting from the cornea were evaluated by videokeratographic data. Main Outcome Measures: Coma-like (S3 + 5), spherical-like (S4 + 6), and total (S3 + 4 + 5 + 6) higher-order aberrations in both refraction and the cornea. Results: The mean +/- standard deviation of S3 + 5 (1.88 +/- 1.16), S4 + 6 (0.70 +/- 0.55), and S3 + 4 + 5 + 6 (2.03 +/- 1.23) in refraction (6-mm diameter, root mean square, p,m) were significantly higher in the keratoconic eyes than in normal controls (0.26 +/- 0.10, 0.19 +/- 0.10, 0.34 +/- 0.11, respectively; Mann-Whitney U test, P = 0.001). Coma-like aberrations were 2.32 times larger than spherical-like aberrations in keratoconic eyes. Conclusions: The increase of ocular higher-order aberrations in keratoconic eyes results from an increase of corneal higher-order aberrations. Coma-like aberrations were dominant compared with spherical-like aberrations in keratoconic eyes. Wavefront sensing will enable us not only to evaluate the quality of vision but also to differentiate keratoconic eyes from normal eyes by analyzing the characteristics of the higher-order aberrations. (C) 2002 by the American Academy of Ophthalmology, Inc.