Intergenerational Effects of Alcohol: A Review of Paternal Preconception Ethanol Exposure Studies and Epigenetic Mechanisms in the Male Germline

被引:51
作者
Rompala, Gregory R. [1 ]
Homanics, Gregg E. [1 ,2 ,3 ,4 ]
机构
[1] Univ Pittsburgh, Sch Med, Ctr Neurosci, Pittsburgh, PA USA
[2] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA USA
[3] Univ Pittsburgh, Sch Med, Dept Anesthesiol & Perioperat Med, Pittsburgh, PA USA
[4] Univ Pittsburgh, Sch Med, Dept Neurobiol, Pittsburgh, PA USA
关键词
Alcohol; Stress; Epigenetic Inheritance; Germline; GENOME-WIDE ASSOCIATION; TRANSFER-RNA; TRANSGENERATIONAL INHERITANCE; DNA METHYLATION; NONCODING RNA; GLUCOCORTICOID-RECEPTOR; PRENATAL EXPOSURE; USE DISORDERS; SPERM RNAS; STRESS;
D O I
10.1111/acer.14029
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
While alcohol use disorder (AUD) is a highly heritable psychiatric disease, efforts to elucidate that heritability by examining genetic variation (e.g., single nucleotide polymorphisms) have been insufficient to fully account for familial AUD risk. Perhaps not coincidently, there has been a burgeoning interest in novel nongenomic mechanisms of inheritance (i.e., epigenetics) that are shaped in the male or female germ cells by significant lifetime experiences such as exposure to chronic stress, malnutrition, or drugs of abuse. While many epidemiological and preclinical studies have long pointed to a role for the parental preconception environment in offspring behavior, over the last decade many studies have implicated a causal relationship between the environmentally sensitive sperm epigenome and intergenerational phenotypes. This critical review will detail the heritable effects of alcohol and the potential role for epigenetics.
引用
收藏
页码:1032 / 1045
页数:14
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