Emerging New Targets for the Treatment of Resistant Fungal Infections

被引：111

作者：

Liu, Na ^{[1
]}

Tu, Jie ^{[1
]}

Dong, Guoqiang ^{[1
]}

Wang, Yan ^{[1
]}

Sheng, Chunquan ^{[1
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, 325 Guohe Rd, Shanghai 200433, Peoples R China

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2018年 / 61卷 / 13期

基金：

中国国家自然科学基金;

关键词：

IN-VITRO ACTIVITY; TRANSFER-RNA SYNTHETASE; BROAD-SPECTRUM ANTIFUNGAL; GLUCAN SYNTHASE INHIBITOR; CELL-CYCLE ARREST; CANDIDA-ALBICANS; ASPERGILLUS-FUMIGATUS; LANOSTEROL; 14-ALPHA-DEMETHYLASE; SACCHAROMYCES-CEREVISIAE; N-MYRISTOYLTRANSFERASE;

D O I：

10.1021/acs.jmedchem.7b01413

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

With the increasing morbidity and mortality of invasive fungal infections and the emergence of severe antifungal drug resistance, new drug targets and novel antifungal agents are urgently needed. Recently, better understanding of fungal pathogenesis has contributed to the rapid emergence of potential antifungal drug targets. This perspective aims to provide a comprehensive review of new antifungal targets and of medicinal chemistry efforts toward inhibitor discovery. Particular focus will be placed on the druggability of the targets and their potential to treat resistant fungal infections. Innovative strategies for the next generation of antifungal therapy, such as virulence factors, protein-protein interactions, and immune response-based proteins, will also be highlighted.

引用

页码：5484 / 5511

页数：28

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