Acute hepatitis induced by alpha-interferon, associated with viral clearance, in chronic hepatitis C

被引：12
作者：
Cervoni, JP
Degos, F
Marcellin, P
Erlinger, S
机构：
[1] HOP BEAUJON,SERV HEPATOL,F-92118 CLICHY,FRANCE
[2] HOP BEAUJON,INSERM U34,UNITE RECH PHYSIOPATHOL HEPAT,F-92118 CLICHY,FRANCE
来源：
JOURNAL OF HEPATOLOGY | 1997年 / 27卷 / 06期
关键词：
autoimmune hepatitis; hepatitis C virus; interferon;
D O I：
10.1016/S0168-8278(97)80157-2
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
We describe the cases of two patients with chronic hepatitis C who developed acute hepatitis with marked amino-transferase elevations and jaundice 3 and 5 months after initiation of interferon treatment. Hepatitis resolved rapidly after cessation of interferon. No autoantibodies were detected. Hepatitis was followed by viral clearance, demonstrated by clearance of hepatitis C viraemia. We propose that hepatitis may be due to an immune lysis of hepatocytes and suggest that this immune response may contribute to viral clearance.
引用
收藏
页码：1113 / 1116
页数：4
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