ABC transporters and isothiocyanates

被引：0

作者：

Kerr, Ian Derek ^{[1
]}

Simpkins, Nigel Simon

机构：

[1] Univ Nottingham, Queens Med Ctr, Sch Biomed Sci, Ctr Biochem & Cell Biol, Nottingham NG7 2UH, England

[2] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2006年 / 3卷 / 09期

关键词：

isothiocyanate; ABC transporter; chemoprevention; multidrug resistance; welwistatin;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Identification of naturally occurring compounds as potential anti-cancer chemotherapy drugs is a prominent research area. Simple dietary isothiocyanates have a spectrum of cellular targets including effects on ATP binding cassette (ABC) transporters, which mediate resistance to chemotherapy. Recent investigations have identified complex compounds, containing an isothiocyanate, which may be more specific inhibitors of ABC transporters.

引用

页码：607 / 621

页数：15

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