Instrumental validation of free water, peak-width of skeletonized mean diffusivity, and white matter hyperintensities: MarkVCID neuroimaging kits

被引：54

作者：

Maillard, Pauline ^{[1
]}

Lu, Hanzhang ^{[2
]}

Arfanakis, Konstantinos ^{[3
,4
]}

Gold, Brian T. T. ^{[5
]}

Bauer, Christopher E. E. ^{[5
]}

Zachariou, Valentinos ^{[5
]}

Stables, Lara ^{[6
]}

Wang, Danny J. J. ^{[7
]}

Jann, Kay ^{[7
]}

Seshadri, Sudha ^{[8
,9
]}

Duering, Marco ^{[10
]}

Hillmer, Laura J. J. ^{[11
]}

Rosenberg, Gary A. A. ^{[11
]}

Snoussi, Haykel ^{[9
]}

Sepehrband, Farshid ^{[7
]}

Habes, Mohamad

Singh, Baljeet ^{[1
]}

Kramer, Joel H. H.

Corriveau, Roderick A. A. ^{[12
]}

Singh, Herpreet ^{[13
]}

Schwab, Kristin ^{[13
]}

Helmer, Karl G. G. ^{[14
,15
]}

Greenberg, Steven M. M. ^{[13
]}

Caprihan, Arvind ^{[16
]}

DeCarli, Charles ^{[1
]}

Satizabal, Claudia L. L. ^{[8
,17
]}

MarkVCID Consortium

机构：

[1] Univ Calif Davis, Dept Neurol, 590 Drew Ave, Davis, CA 95616 USA

[2] Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD USA

[3] IIT, Dept Biomed Engn, Chicago, IL USA

[4] Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Dept Diagnost Radiol & Nucl Med, Chicago, IL USA

[5] Univ Kentucky, Dept Neurosci, Lexington, KY USA

[6] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[7] Univ Southern Calif, Stevens Neuroimaging & Informat Inst, Keck Sch Med, Lab FMRI Technol LOFT, Los Angeles, CA USA

[8] Boston Univ, Sch Med, Dept Neurol, Boston, MA USA

[9] Univ Texas Hlth San Antonio, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA

[10] Univ Basel, Med Image Anal Ctr MIAC AG, Dept Biomed Engn, Basel, Switzerland

[11] Univ New Mexico, Dept Neurol, Albuquerque, NM USA

[12] NINDS, Bethesda, MD USA

[13] Massachusetts Gen Hosp, Dept Neurol, Boston, MA USA

[14] Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA

[15] Harvard Med Sch, Dept Radiol, Boston, MA USA

[16] Mind Res Network, Albuquerque, NM USA

[17] Univ Texas Hlth San Antonio, Dept Populat Hlth Sci, San Antonio, TX USA

来源：

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | 2022年 / 14卷 / 01期

关键词：

biomarker; diffusion tensor imaging; free water; magnetic resonance imaging; peak-width skeletonized mean diffusivity; small vessel disease; vascular contributions to cognitive impairment and dementia; VCID; white matter hyperintensity; white matter injury; VOLUME; INTEGRITY; MRI;

D O I：

10.1002/dad2.12261

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IntroductionTo describe the protocol and findings of the instrumental validation of three imaging-based biomarker kits selected by the MarkVCID consortium: free water (FW) and peak width of skeletonized mean diffusivity (PSMD), both derived from diffusion tensor imaging (DTI), and white matter hyperintensity (WMH) volume derived from fluid attenuation inversion recovery and T1-weighted imaging. MethodsThe instrumental validation of imaging-based biomarker kits included inter-rater reliability among participating sites, test-retest repeatability, and inter-scanner reproducibility across three types of magnetic resonance imaging (MRI) scanners using intra-class correlation coefficients (ICC). ResultsThe three biomarkers demonstrated excellent inter-rater reliability (ICC >0.94, P-values < .001), very high agreement between test and retest sessions (ICC >0.98, P-values < .001), and were extremely consistent across the three scanners (ICC >0.98, P-values < .001). DiscussionThe three biomarker kits demonstrated very high inter-rater reliability, test-retest repeatability, and inter-scanner reproducibility, offering robust biomarkers suitable for future multi-site observational studies and clinical trials in the context of vascular cognitive impairment and dementia (VCID).

引用

页数：14

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