High In Vitro Activity of the Novel Spiropyrimidinetrione AZD0914, a DNA Gyrase Inhibitor, against Multidrug-Resistant Neisseria gonorrhoeae Isolates Suggests a New Effective Option for Oral Treatment of Gonorrhea

被引：66

作者：

Jacobsson, Susanne ^{[1
]}

Golparian, Daniel ^{[1
]}

Alm, Richard A. ^{[2
]}

Huband, Michael ^{[2
]}

Mueller, John ^{[2
]}

Jensen, Jorgen Skov ^{[3
]}

Ohnishi, Makoto ^{[4
]}

Unemo, Magnus ^{[1
]}

机构：

[1] Orebro Univ Hosp, WHO Collaborating Ctr Gonorrhoea & other Sexually, Dept Lab Med Clin Microbiol, Natl Reference Lab Pathogen Neisseria, Orebro, Sweden

[2] AstraZeneca R&D Boston, Infect iMed, Waltham, MA USA

[3] Statens Serum Inst, DK-2300 Copenhagen, Denmark

[4] Natl Inst Infect Dis, Tokyo, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 09期

关键词：

GENETIC-CHARACTERIZATION; CEFIXIME TREATMENT; TREATMENT FAILURE; CEFTRIAXONE; STRAIN;

D O I：

10.1128/AAC.03090-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We evaluated the activity of the novel spiropyrimidinetrione AZD0914 (DNA gyrase inhibitor) against clinical gonococcal isolates and international reference strains (n = 250), including strains with diverse multidrug resistance and extensive drug resistance. The AZD0914 MICs were substantially lower than those of most other currently or previously recommended antimicrobials. AZD0914 should be further evaluated, including in vitro selection, in vivo emergence and mechanisms of resistance, pharmacokinetics/pharmacodynamics in humans, optimal dosing, and performance, in appropriate randomized and controlled clinical trials.

引用

页码：5585 / 5588

页数：4

共 33 条

[1] Neisseria gonorrhoeae Treatment Failure and Susceptibility to Cefixime in Toronto, Canada [J].

Allen, Vanessa G. ;

Mitterni, Leo ;

Seah, Christine ;

Rebbapragada, Anuradha ;

Martin, Irene E. ;

Lee, Colin ;

Siebert, Heather ;

Towns, Lynn ;

Melano, Roberto G. ;

Low, Donald E. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 309 (02) :163-170

[2]

[Anonymous], 2011, 24 INFORMATIONAL SUP

[3]

[Anonymous], 2012, Regional Innovation Scoreboard 2012, P1, DOI DOI 10.2833/10759

[4]

[Anonymous], 53 INT C ANT AG CHEM

[5] 2012 European guideline on the diagnosis and treatment of gonorrhoea in adults [J].

Bignell, C. ;

Unemo, M. .

INTERNATIONAL JOURNAL OF STD & AIDS, 2013, 24 (02) :85-92

[6] Molecular characterization of two high-level ceftriaxone-resistant Neisseria gonorrhoeae isolates detected in Catalonia, Spain [J].

Camara, Jordi ;

Serra, Judit ;

Ayats, Josefina ;

Bastida, Teresa ;

Carnicer-Pont, Dolors ;

Andreu, Antonia ;

Ardanuy, Carmen .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2012, 67 (08) :1858-1860

[7]

Centers for Disease Control and Prevention (CDC), 2012, CEPH RES NEISS GON P, P1

[8] Exploiting bacterial DNA gyrase as a drug target: current state and perspectives [J].

Collin, Frederic ;

Karkare, Shantanu ;

Maxwell, Anthony .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2011, 92 (03) :479-497

[9]

del Rio Carlos, 2012, Morbidity and Mortality Weekly Report, V61, P590

[10]

European Committee on Antimicrobial Susceptibility Testing, 2014, BREAKP TABL INT MICS

← 1 2 3 4 →