Extraction of phenolic compounds from rosemary using choline chloride - based Deep Eutectic Solvents

被引：109

作者：

Wojeicchowski, Jose Pedro ^{[1
,2
]}

Marques, Caroline ^{[1
]}

Igarashi-Mafra, Luciana ^{[1
]}

Coutinho, Joao A. P. ^{[2
]}

Mafra, Marcos R. ^{[1
]}

机构：

[1] Fed Univ Parana UFPR, Dept Chem Engn, Polytech Ctr, BR-81531990 Curitiba, Parana, Brazil

[2] Univ Aveiro UA, Dept Chem, Aveiro Inst Mat, CICECO, P-3810193 Aveiro, Portugal

来源：

SEPARATION AND PURIFICATION TECHNOLOGY | 2021年 / 258卷

关键词：

Solubility; Carnosic acid; Carnosol; Rosmarinic acid; COSMO-RS; COSMO-RS; ANTIMICROBIAL ACTIVITIES; ASSISTED EXTRACTION; BIOACTIVE COMPOUNDS; IONIC LIQUIDS; CARNOSIC ACID; ANTIOXIDANT; ANTIBACTERIAL; CHEMISTRY; DESIGN;

D O I：

10.1016/j.seppur.2020.117975

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Deep eutectic solvents (DES) have been explored as an alternative to hazardous solvents to extract natural bioactive compounds. In this work, choline chloride-based DES (neat and hydrated) were assessed in the extraction of phenolics from rosemary leaves. The DES studied on an initial screening showed a total phenolic content (TPC) up to 220% higher than the control. The solubilities of the main rosemary biocompounds, estimated by COSMO-RS, showed a positive correlation to TPC. Choline chloride:1,2-propanediol (CPH) was selected for further optimization. At the optimal conditions (65 degrees C, liquid: solid ratio of 40:1 and 50 %wt of water), the antioxidant activity and TPC were 80 mg of Trolox equivalent/g and 78 mg of gallic acid equivalent/g, respectively. The antimicrobial activity of the optimized extract revealed inhibition of 39-51% to all bacteria tested. In summary, an extract with good antioxidant and antimicrobial activities was obtained from rosemary leaves using CPH as solvent.

引用

页数：8

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