Comparison of Amyloid Plaque Contrast Generated by T2-Weighted, T2☆-Weighted, and Susceptibility-Weighted Imaging Methods in Transgenic Mouse Models of Alzheimer's Disease

被引:51
作者
Chamberlain, Ryan [2 ,4 ]
Reyes, Denise [1 ]
Curran, Geoffrey L. [3 ,5 ,6 ]
Marjanska, Malgorzata [2 ,4 ]
Wengenack, Thomas M. [3 ,5 ,6 ]
Poduslo, Joseph F. [3 ,5 ,6 ]
Garwood, Michael [2 ,4 ]
Jack, Clifford R., Jr. [1 ]
机构
[1] Mayo Clin, Coll Med, Dept Radiol, Rochester, MN 55905 USA
[2] Univ Minnesota, Sch Med, Ctr Magnet Resonance Res, Minneapolis, MN 55455 USA
[3] Mayo Clin, Coll Med, Dept Neurol, Rochester, MN 55905 USA
[4] Univ Minnesota, Sch Med, Dept Radiol, Minneapolis, MN 55455 USA
[5] Mayo Clin, Coll Med, Dept Neurosci, Rochester, MN 55905 USA
[6] Mayo Clin, Coll Med, Dept Biochem Mol Biol, Rochester, MN 55905 USA
基金
美国国家卫生研究院;
关键词
MR microscopy; Alzheimer's disease; magnetic resonance imaging; magnetic resonance microimaging; transgenic mice; susceptibility-weighted imaging; NEURITIC PLAQUES; MICE; IRON; VISUALIZATION; MICROSCOPY; BURDEN; BRAIN;
D O I
10.1002/mrm.21951
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
One of the hallmark pathologies of Alzheimer's disease (AD) is amyloid plaque deposition. Plaques appear hypointense on T(2)-weighted and T(2)(star)-weighted MR images probably due to the presence of endogenous iron, but no quantitative comparison of various imaging techniques has been reported. We estimate the T(1), T(2), T(2)(star), and proton density values of cortical plaques an normal cortical tissue and analyzed the plaque contrast generated by a collection of T(2)-weighted, T(2)(star)-weighted, and susceptibility-weighted imaging (SWI) methods in ex vivo transgenic mouse specimens. The proton density and T(1), values were similar for both cortical plaques and normal cortical tissue. The T(2) and T(2)(star) values were similar in cortical plaques, which indicate that the iron content of cortical plaques may not be as large a previously thought. Ex vivo plaque contrast was increase compared to a previously reported spin-echo sequence by summing multiple echoes and by performing SWI; however gradient echo and SWI were found to be impractical for in vivo imaging due to susceptibility interface-related signal loss in the cortex. Magn Reson Med 61:1158-1164, 2009. (C) 2009 Wiley-Liss, Inc.
引用
收藏
页码:1158 / 1164
页数:7
相关论文
共 26 条
[1]   Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy [J].
Benveniste, H ;
Einstein, G ;
Kim, KR ;
Hulette, C ;
Johnson, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (24) :14079-14084
[2]   In vivo measurement of plaque burden in a mouse model of Alzheimer's disease [J].
Borthakur, Arijitt ;
Gur, Tamar ;
Wheaton, Andrew J. ;
Corbo, Matthew ;
Trojanowski, John Q. ;
Lee, Virginia M. -Y. ;
Reddy, Ravinder .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2006, 24 (05) :1011-1017
[3]   Longitudinal assessment of Alzheimer's β-amyloid plaque development in transgenic mice monitored by in vivo magnetic resonance microimaging [J].
Braakman, Niels ;
Matysik, Jorg ;
van Duinen, Sjoerd G. ;
Verbeek, Fons ;
Schliebs, Reinhard ;
de Groot, Huub J. M. ;
Alia, A. .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2006, 24 (03) :530-536
[4]   CONTRAST, RESOLUTION, AND DETECTABILITY IN MR IMAGING [J].
CONSTABLE, RT ;
HENKELMAN, RM .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1991, 15 (02) :297-303
[5]   THE LOSS OF SMALL OBJECTS IN VARIABLE TE IMAGING - IMPLICATIONS FOR FSE, RARE, AND EPI [J].
CONSTABLE, RT ;
GORE, JC .
MAGNETIC RESONANCE IN MEDICINE, 1992, 28 (01) :9-24
[6]   Senile plaques do not induce susceptibility effects in T2*-weighted MR microscopic images [J].
Dhenain, M ;
Privat, N ;
Duyckaerts, C ;
Jacobs, RE .
NMR IN BIOMEDICINE, 2002, 15 (03) :197-203
[7]   Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice [J].
Dhenain, Marc ;
El Tayara, Nadine El Tannir ;
Wu, Ting-Di ;
Guegan, Maryvonne ;
Volk, Andreas ;
Quintana, Carmen ;
Delatour, Benoit .
NEUROBIOLOGY OF AGING, 2009, 30 (01) :41-53
[8]   Transverse relaxation time reflects brain amyloidosis in young APP/PS1 transgenic mice [J].
El Tayara, Nadine El Tannir ;
Volk, Andreas ;
Dhenain, Marc ;
Delatour, Benoit .
MAGNETIC RESONANCE IN MEDICINE, 2007, 58 (01) :179-184
[9]   Age-related evolution of amyloid burden, iron load, and MR relaxation times in a transgenic mouse model of Alzheimer's disease [J].
El Tayara, NE ;
Delatour, B ;
Le Cudennec, C ;
Guégan, M ;
Volk, A ;
Dhenain, M .
NEUROBIOLOGY OF DISEASE, 2006, 22 (01) :199-208
[10]  
Faber C, 2007, MAGN RESON MED, V57, P696, DOI [10.1002/mrm.21201, 10.1002/mrm.21021]