DNA-interaction and in vitro antimicrobial studies of some mixed-ligand complexes of cobalt(II) with fluoroquinolone antibacterial agent ciprofloxacin and some neutral bidentate ligands

被引：29

作者：

Patel, M. N. ^{[1
]}

Chhasatia, M. R. ^{[1
]}

Gandhi, D. S. ^{[1
]}

机构：

[1] Sardar Patel Univ, Dept Chem, Vallabh Vidyanagar 388120, Gujarat, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 10期

关键词：

Mixed-ligand complexes of cobalt(II); MIC; Oxidative cleavage; Binding constant (K-b); STRUCTURAL-CHARACTERIZATION; CRYSTAL-STRUCTURE; CLEAVAGE ACTIVITY; SCHIFF-BASE; COPPER(II) COMPLEXES; NICKEL(II); BINDING; IONS;

D O I：

10.1016/j.bmcl.2009.03.078

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six new mixed-ligand complexes of Co(II) with ciprofloxacin (Cip) and neutral bidentate ligands have been synthesized and characterized. Binding and cleavage of DNA with the complex were investigated using spectroscopic method, viscosity measurements and gel electrophoresis techniques. Antibacterial activity has been assayed against two Gram((ve)) and three Gram((+ve)) microorganisms using the doubling dilution technique. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2870 / 2873

页数：4

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