The iap genes: unique arbitrators of cell death

被引：86

作者：

Clem, RJ ^{[1
]}

Duckett, CS ^{[1
]}

机构：

[1] UNIV CHICAGO,GWEN KNAPP CTR LUPUS & IMMUNOL RES,CHICAGO,IL 60637

来源：

TRENDS IN CELL BIOLOGY | 1997年 / 7卷 / 09期

关键词：

D O I：

10.1016/S0962-8924(97)01088-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The iap family of anti-apoptotic genes, originally discovered in viruses, has grown considerably ipl the past two years with the addition of a number of evolutionarily conserved cellular homologues. Although the mechanism(s) by which these novel proteins block cell death is still unknown, intriguing clues to their function have been revealed by the discovery of interactions between Some of the IAP homologues and cellular proteins involved in carrying out apoptotic signalling. Here, Rollie Clem and Colin Duckett discuss how the various IAP proteins may function in regulating apoptosis.

引用

页码：337 / 339

页数：3

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