Lipase-catalyzed synthesis of MPEG methyl acrylates in solvent-free system

被引：3
|
作者：
Wang, Jing [1 ]
Ying, Hanxiao [1 ]
Ma, Jinlian [1 ]
Cao, Xun [1 ]
Chen, Kequan [1 ]
Ge, Jun [2 ]
Pingkai, Ouyang [1 ]
机构：
[1] Nanjing Univ Technol, Coll Life Sci & Pharm, State Key Lab Mat Oriented Chem Engn, Nanjing 211816, Jiangsu, Peoples R China
[2] Tsinghua Univ, Dept Chem Engn, Beijing 10000, Peoples R China
来源：
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2015年 / 122卷
关键词：
Enzymatic synthesis; MPEG methyl acrylate (MPEGMA); Immobilized enzyme; Lipase; ENZYMATIC-SYNTHESIS; IMMOBILIZED LIPASE; ORGANIC-SOLVENTS; PEROXYCARBOXYLIC ACIDS; SUPERPLASTICIZERS; ESTERIFICATION; CEMENT; TRANSESTERIFICATION; BIOCATALYSIS; OPTIMIZATION;
D O I：
10.1016/j.molcatb.2015.10.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The first enzymatic synthesis of the polycarboxylate superplasticizer monomer, MPEG methyl acrylate (MPEGMA) in solvent-free system was established using Novozym 435, an immobilized lipase, as the catalyst, mPEG and methyl acrylic acid (MAA) as the substrates. At the optimal condition, 10% (w/w) enzyme catalyst loading and molar ratio of mPEG to MAA as 1:1, the esterification yield in such solvent-free system at 60 degrees C reached 76.2%, 1.14-fold higher than that obtained using paraxylene as solvent. A kinetic model for this solvent-free enzymatic synthesis was proposed on the basis of ping-pong bi-bi mechanism and was validated by the good agreement between the predicted data and the experimental results. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：305 / 313
页数：9
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