Salmonella takes control: effector-driven manipulation of the host

被引：248

作者：

McGhie, Emma J. ^{[1
]}

Brawn, Lyndsey C. ^{[1
]}

Hume, Peter J. ^{[1
]}

Humphreys, Daniel ^{[1
]}

Koronakis, Vassilis ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

来源：

CURRENT OPINION IN MICROBIOLOGY | 2009年 / 12卷 / 01期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

PHOSPHOTHREONINE LYASE ACTIVITY; CONTAINING VACUOLE; PROTEIN-TRANSPORT; TYPHIMURIUM; SIPA; SOPB; VIRULENCE; MEMBRANE; DYNAMICS; SSEJ;

D O I：

10.1016/j.mib.2008.12.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Salmonella pathogenesis relies upon the delivery of over thirty specialised effector proteins into the host cell via two distinct type III secretion systems. These effectors act in concert to subvert the host cell cytoskeleton, signal transduction pathways, membrane trafficking and pro-inflammatory responses. This allows Salmonella to invade non-phagocytic epithelial cells, establish and maintain an intracellular replicative niche and, in some cases, disseminate to cause systemic disease. This review focuses on the actions of the effectors on their host cell targets during each stage of Salmonella infection.

引用

页码：117 / 124

页数：8

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