Antimicrobial peptides from echinoderms as antibiofilm agents: a natural strategy to combat bacterial infections

被引:5
|
作者
Schillaci, D. [1 ]
Cusimano, M. G. [1 ]
Russo, D. [1 ,2 ]
Arizza, V. [1 ,2 ]
机构
[1] Univ Palermo, Dip STEBICEF, I-90123 Palermo, Italy
[2] Ist Euromediterraneo Sci & Biotecnol, Dip Key SET, Palermo, Italy
关键词
Antimicrobial peptides; echinoderm; Paracentrotus lividus; Holothuria tubulosa; antibiofilm; HOST-DEFENSE PEPTIDES; GREEN SEA-URCHIN; ANTIBACTERIAL ACTIVITY; PARACENTROTUS-LIVIDUS; PATHOGENIC BACTERIA; BIOFILM FORMATION; BETA-THYMOSINS; LYTIC SYSTEM; GROWTH-RATE; ANTIBIOTICS;
D O I
10.1080/11250003.2014.922128
中图分类号
Q95 [动物学];
学科分类号
071002 ;
摘要
Increased attention has been focused on marine invertebrates as a source of bioactive molecules for biomedical applications. Many bioactive molecules are part of the innate immune system. Some more recently isolated compounds, mainly from the sea urchin and the sea cucumber, are antimicrobial peptides (AMPs) active against Gram-positive and Gram-negative bacteria, and fungi. In this review we described the most recent studies on AMPs isolated from echinoderms. AMPs are small peptides (< 10 kDa) with cationic charge and amphipathic structure. Recently, it was demonstrated that in the coelomocyte lysates of Paracentrotus lividus and Holothuria tubulosa, AMPs possess activity against staphylococcal and Pseudomonas aeruginosa biofilms. The data shows a great potential for application of AMPs in biotechnology for developing novel therapeutic agents that are either alternative or complementary to conventional antibiotic therapy to combat multiresistant pathogens.
引用
收藏
页码:312 / 321
页数:10
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