Hypoxia and the extracellular matrix: drivers of tumour metastasis

被引：1185

作者：

Gilkes, Daniele M. ^{[1
,2
,3
]}

Semenza, Gregg L. ^{[1
,2
,3
,4
,5
,6
,7
,8
]}

Wirtz, Denis ^{[3
,9
,10
,11
,12
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Vasc Program, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Inst Med Genet, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Johns Hopkins Phys Sci Oncol Ctr, Baltimore, MD 21218 USA

[4] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[7] Johns Hopkins Univ, Sch Med, Dept Radiat Oncol, Baltimore, MD 21205 USA

[8] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

[9] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA

[10] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[11] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[12] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21205 USA

来源：

NATURE REVIEWS CANCER | 2014年 / 14卷 / 06期

关键词：

BREAST-CANCER METASTASIS; FOCAL ADHESION KINASE; INDUCIBLE FACTOR-I; EPITHELIAL-SPECIFIC DISRUPTION; 3-DIMENSIONAL CELL-MIGRATION; COLLAGEN CROSS-LINKING; PAS DOMAIN PROTEIN-1; GROWTH-FACTOR-B; GENE-EXPRESSION; LYSYL OXIDASE;

D O I：

10.1038/nrc3726

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Of the deaths attributed to cancer, 90% are due to metastasis, and treatments that prevent or cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular matrix (ECM) might have crucial roles in metastasis. During tumour evolution, changes in the composition and the overall content of the ECM reflect both its biophysical and biological properties and these strongly influence tumour and stromal cell properties, such as proliferation and motility. Originally thought of as independent contributors to metastatic spread, recent studies have established a direct link between hypoxia and the composition and the organization of the ECM, which suggests a new model in which multiple microenvironmental signals might converge to synergistically influence metastatic outcome.

引用

页码：430 / 439

页数：10

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