Paclitaxel: biosynthesis, production and future prospects

被引：144

作者：

Howat, Susan ^{[1
]}

Park, Bora ^{[1
,2
]}

Oh, Il Suk ^{[2
]}

Jin, Young-Woo ^{[2
]}

Lee, Eun-Kyong ^{[2
]}

Loake, Gary J. ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Biol Sci, Inst Mol Plant Sci, Edinburgh EH9 3JR, Midlothian, Scotland

[2] Unhwa Corp, Jeonju, South Korea

来源：

NEW BIOTECHNOLOGY | 2014年 / 31卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

PLANT-CELL CULTURE; 1ST TOTAL-SYNTHESIS; NATURAL-PRODUCT; ISOPRENOID BIOSYNTHESIS; TAXOL; TAXUS; TAXADIENE; TAXA-4(5); 11(12)-DIENE; RING;

D O I：

10.1016/j.nbt.2014.02.010

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Plants are capable of producing a wide variety of secondary metabolites which have a diverse range of functions that can be exploited for medicinal purposes; for example, paclitaxel is a major anti-cancer drug found in the bark of Taxus spp. There are however supply issues as the compound is only found at low concentrations (0.05%) within the plant. The complex paclitaxel biosynthetic pathway makes chemical synthesis non-commercially viable; therefore alternative biotechnological sources have been explored for production including heterologous expression systems and plant cell culture.

引用

页码：242 / 245

页数：4

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