Adipose tissue stem cells in peripheral nerve regeneration-In vitroandin vivo

被引:38
作者
Rhode, Sophie Charlotte [1 ]
Beier, Justus Patrick [1 ]
Ruhl, Tim [1 ]
机构
[1] Univ Hosp RWTH Aachen, Dept Plast Surg, Hand Surg & Burn Ctr, Pauwelsstr 30, D-52074 Aachen, Germany
关键词
differentiation; growth factor; nerve injury; Schwann cells; Schwann cell-like cells; AUTOLOGOUS SCHWANN-CELLS; CILIARY NEUROTROPHIC FACTOR; SCIATIC-NERVE; WALLERIAN DEGENERATION; MYELIN; INJURY; REPAIR; RAT; CONDUIT; PROTEIN;
D O I
10.1002/jnr.24738
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
After peripheral nerve injury, Schwann cells (SCs) are crucially involved in several steps of the subsequent regenerative processes, such as the Wallerian degeneration. They promote lysis and phagocytosis of myelin, secrete numbers of neurotrophic factors and cytokines, and recruit macrophages for a biological debridement. However, nerve injuries with a defect size of >1 cm do not show proper tissue regeneration and require a surgical nerve gap reconstruction. To find a sufficient alternative to the current gold standard-the autologous nerve transplant-several cell-based therapies have been developed and were experimentally investigated. One approach aims on the use of adipose tissue stem cells (ASCs). These are multipotent mesenchymal stromal cells that can differentiate into multiple phenotypes along the mesodermal lineage, such as osteoblasts, chondrocytes, and myocytes. Furthermore, ASCs also possess neurotrophic features, that is, they secrete neurotrophic factors like the nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, ciliary neurotrophic factor, glial cell-derived neurotrophic factor, and artemin. They can also differentiate into the so-called Schwann cell-like cells (SCLCs). These cells share features with naturally occurring SCs, as they also promote nerve regeneration in the periphery. This review gives a comprehensive overview of the use of ASCs in peripheral nerve regeneration and peripheral nerve tissue engineering bothin vitroandin vivo. While the sustainability of differentiation of ASCs to SCLCsin vivois still questionable, ASCs used with different nerve conduits, such as hydrogels or silk fibers, have been shown to promote nerve regeneration.
引用
收藏
页码:545 / 560
页数:16
相关论文
共 113 条
[11]   Myelin-Associated Glycoprotein Inhibits Schwann Cell Migration and Induces Their Death [J].
Chaudhry, Nagarathnamma ;
Bachelin, Corinne ;
Zujovic, Violetta ;
Hilaire, Melissa ;
Baldwin, Katherine T. ;
Follis, Rose M. ;
Giger, Roman ;
Carter, Bruce D. ;
Baron-Van Evercooren, Anne ;
Filbin, Marie T. .
JOURNAL OF NEUROSCIENCE, 2017, 37 (24) :5885-5899
[12]   The neuroprotective roles of BDNF in hypoxic ischemic brain injury (Review) [J].
Chen, Ai ;
Xiong, Li-Jing ;
Tong, Yu ;
Mao, Meng .
BIOMEDICAL REPORTS, 2013, 1 (02) :167-176
[13]   Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury [J].
Chen, Peiwen ;
Piao, Xianhua ;
Bonaldo, Paolo .
ACTA NEUROPATHOLOGICA, 2015, 130 (05) :605-618
[14]   Use of human fat grafting in the prevention of perineural adherence: Experimental study in athymic mouse [J].
Cherubino, Mario ;
Pellegatta, Igor ;
Crosio, Alessandro ;
Valdatta, Luigi ;
Geuna, Stefano ;
Gornati, Rosalba ;
Tos, Pierluigi .
PLOS ONE, 2017, 12 (04)
[15]   A PROSPECTIVE CLINICAL-EVALUATION OF AUTOGENOUS VEIN GRAFTS USED AS A NERVE CONDUIT FOR DISTAL SENSORY NERVE DEFECTS OF 3 CM OR LESS [J].
CHIU, DTW ;
STRAUCH, B .
PLASTIC AND RECONSTRUCTIVE SURGERY, 1990, 86 (05) :928-934
[16]   Large-scale production of human adipose tissue from stem cells: A new tool for regenerative medicine and tissue banking [J].
D'Andrea, Francesco ;
De Francesco, Francesco ;
Ferraro, Giuseppe A. ;
Desiderio, Vincenzo ;
Tirino, Virginia ;
De Rosa, Alfredo ;
Papaccio, Gianpaolo .
TISSUE ENGINEERING PART C-METHODS, 2008, 14 (03) :233-242
[17]   TECHNIQUES OF PERIPHERAL NERVE REPAIR [J].
Dahlin, L. B. .
SCANDINAVIAN JOURNAL OF SURGERY, 2008, 97 (04) :310-316
[18]   In vitro evaluation of gel-encapsulated adipose derived stem cells: Biochemical cues for in vivo peripheral nerve repair [J].
de Luca, A. C. ;
Fonta, C. M. ;
Raffoul, W. ;
di Summa, P. G. ;
Lacour, S. P. .
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2018, 12 (03) :676-686
[19]   THE 1ST NERVE GRAFT, VULPIAN, AND THE 19TH-CENTURY NEURAL REGENERATION CONTROVERSY [J].
DELLON, ES ;
DELLON, AL .
JOURNAL OF HAND SURGERY-AMERICAN VOLUME, 1993, 18A (02) :369-372
[20]   Adipose Derived Stem Cells Reduce Fibrosis and Promote Nerve Regeneration in Rats [J].
Di Summa, Pietro G. ;
Schiraldi, Luigi ;
Cherubino, Mario ;
Oranges, Carlo M. ;
Kalbermatten, Daniel F. ;
Raffoul, Wassim ;
Madduri, Srinivas .
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, 2018, 301 (10) :1714-1721