MicroRNA signatures in human cancers

被引：6606
作者：
Calin, George A.
Croce, Carlo M. [1 ]
机构：
[1] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA
[2] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
来源：
NATURE REVIEWS CANCER | 2006年 / 6卷 / 11期
关键词：
D O I：
10.1038/nrc1997
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNA (miRNA) alterations are involved in the initiation and progression of human cancer. The causes of the widespread differential expression of miRNA genes in malignant compared with normal cells can be explained by the location of these genes in cancer-associated genomic regions, by epigenetic mechanisms and by alterations in the miRNA processing machinery. MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. In addition, profiling has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer.
引用
收藏
页码：857 / 866
页数：10
相关论文
共 113 条
[81]   MicroRNAs and cancer [J].
McManus, MT .
SEMINARS IN CANCER BIOLOGY, 2003, 13 (04) :253-258
[82]   Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines [J].
Meng, Fanyin ;
Henson, Roger ;
Lang, Molly ;
Wehbe, Hania ;
Maheshwari, Shail ;
Mendell, Joshua T. ;
Jiang, Jinmai ;
Schmittgen, Thomas D. ;
Patel, Tushar .
GASTROENTEROLOGY, 2006, 130 (07) :2113-2129
[83]   High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma [J].
Metzler, M ;
Wilda, M ;
Busch, K ;
Viehmann, S ;
Borkhardt, A .
GENES CHROMOSOMES & CANCER, 2004, 39 (02) :167-169
[84]   Genetic analysis of genome-wide variation in human gene expression [J].
Morley, M ;
Molony, CM ;
Weber, TM ;
Devlin, JL ;
Ewens, KG ;
Spielman, RS ;
Cheung, VG .
NATURE, 2004, 430 (7001) :743-747
[85]   Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues [J].
Murakami, Y ;
Yasuda, T ;
Saigo, K ;
Urashima, T ;
Toyoda, H ;
Okanoue, T ;
Shimotohno, K .
ONCOGENE, 2006, 25 (17) :2537-2545
[86]   Abnormal expression of apoptosis-related genes in haematological malignancies:: overexpression of MYC is poor prognostic sign in mantle cell lymphoma [J].
Nagy, B ;
Lundán, T ;
Larramendy, ML ;
Aalto, Y ;
Zhu, Y ;
Niini, T ;
Edgren, H ;
Ferrer, A ;
Vilpo, J ;
Elonen, E ;
Vettenranta, K ;
Franssila, K ;
Knuutila, S .
BRITISH JOURNAL OF HAEMATOLOGY, 2003, 120 (03) :434-441
[87]   Microarray-based, high-throughput gene expression profiling of microRNAs [J].
Nelson, PT ;
Baldwin, DA ;
Scearce, LM ;
Oberholtzer, JC ;
Tobias, JW ;
Mourelatos, Z .
NATURE METHODS, 2004, 1 (02) :155-161
[88]   c-Myc-regulated microRNAs modulate E2F1 expression [J].
O'Donnell, KA ;
Wentzel, EA ;
Zeller, KI ;
Dang, CV ;
Mendell, JT .
NATURE, 2005, 435 (7043) :839-843
[89]   LNA-modified oligonucleotides mediate specific inhibition of microRNA function [J].
Orom, Ulf Andersson ;
Kauppinen, Sakari ;
Lund, Anders H. .
GENE, 2006, 372 :137-141
[90]   MicroRNA deregulation in human thyroid papillary carcinomas [J].
Pallante, P. ;
Visone, R. ;
Ferracin, M. ;
Ferraro, A. ;
Berlingieri, M. T. ;
Troncone, G. ;
Chiappetta, G. ;
Liu, C. G. ;
Santoro, M. ;
Negrini, M. ;
Croce, C. M. ;
Fusco, A. .
ENDOCRINE-RELATED CANCER, 2006, 13 (02) :497-508
3456789101112