MicroRNA signatures in human cancers

被引：6529
作者：
Calin, George A.
Croce, Carlo M. [1 ]
机构：
[1] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA
[2] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
来源：
NATURE REVIEWS CANCER | 2006年 / 6卷 / 11期
关键词：
D O I：
10.1038/nrc1997
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNA (miRNA) alterations are involved in the initiation and progression of human cancer. The causes of the widespread differential expression of miRNA genes in malignant compared with normal cells can be explained by the location of these genes in cancer-associated genomic regions, by epigenetic mechanisms and by alterations in the miRNA processing machinery. MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. In addition, profiling has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer.
引用
收藏
页码：857 / 866
页数：10
相关论文
共 113 条
  • [1] Sequence variants in SLITRK1 are associated with Tourette's syndrome
    Abelson, JF
    Kwan, KY
    O'Roak, BJ
    Baek, DY
    Stillman, AA
    Morgan, TM
    Mathews, CA
    Pauls, DA
    Rasin, MR
    Gunel, M
    Davis, NR
    Ercan-Sencicek, AG
    Guez, DH
    Spertus, JA
    Leckman, JF
    Dure, LS
    Kurlan, R
    Singer, HS
    Gilbert, DL
    Farhi, A
    Louvi, A
    Lifton, RP
    Sestan, N
    State, MW
    [J]. SCIENCE, 2005, 310 (5746) : 317 - 320
  • [2] PREFERENTIAL LINKAGE OF BCL-2 TO IMMUNOGLOBULIN LIGHT CHAIN GENE IN CHRONIC LYMPHOCYTIC-LEUKEMIA
    ADACHI, M
    TEFFERI, A
    GREIPP, PR
    KIPPS, TJ
    TSUJIMOTO, Y
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (02) : 559 - 564
  • [3] Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity
    Ali, IU
    Schriml, LM
    Dean, M
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (22): : 1922 - 1932
  • [4] The functions of animal microRNAs
    Ambros, V
    [J]. NATURE, 2004, 431 (7006) : 350 - 355
  • [5] A novel class of small RNAs bind to MILI protein in mouse testes
    Aravin, Alexei
    Gaidatzis, Dimos
    Pfeffer, Sebastien
    Lagos-Quintana, Mariana
    Landgraf, Pablo
    Iovino, Nicola
    Morris, Patricia
    Brownstein, Michael J.
    Kuramochi-Miyagawa, Satomi
    Nakano, Toru
    Chien, Minchen
    Russo, James J.
    Ju, Jingyue
    Sheridan, Robert
    Sander, Chris
    Zavolan, Mihaela
    Tuschl, Thomas
    [J]. NATURE, 2006, 442 (7099) : 203 - 207
  • [6] Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs
    Bartel, DP
    Chen, CZ
    [J]. NATURE REVIEWS GENETICS, 2004, 5 (05) : 396 - 400
  • [7] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004)
    Bartel, David P.
    [J]. CELL, 2007, 131 (04) : 11 - 29
  • [8] The 2004 World Health Organization classification of lung tumors
    Beasley, MB
    Brambilla, E
    Travis, WD
    [J]. SEMINARS IN ROENTGENOLOGY, 2005, 40 (02) : 90 - 97
  • [9] Identification of hundreds of conserved and nonconserved human microRNAs
    Bentwich, I
    Avniel, A
    Karov, Y
    Aharonov, R
    Gilad, S
    Barad, O
    Barzilai, A
    Einat, P
    Einav, U
    Meiri, E
    Sharon, E
    Spector, Y
    Bentwich, Z
    [J]. NATURE GENETICS, 2005, 37 (07) : 766 - 770
  • [10] Phylogenetic shadowing and computational identification of human microRNA genes
    Berezikov, E
    Guryev, V
    van de Belt, J
    Wienholds, E
    Plasterk, RHA
    Cuppen, E
    [J]. CELL, 2005, 120 (01) : 21 - 24
12345678910