Role of AMPA receptors in synaptic plasticity

被引:66
|
作者
Sprengel, Rolf [1 ]
机构
[1] Max Planck Inst Med Res, D-69120 Heidelberg, Germany
关键词
AMPA receptors; long-term potentiation; RNA editing; spatial working and reference memory; stargazin;
D O I
10.1007/s00441-006-0275-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the principal molecular units for fast excitatory synaptic transmission in the central nervous system. The glutamate-mediated transmission efficiency of synaptic AMPA receptors is influenced by their subunit composition (GluR-A to GluR-D), post-transcriptional and post-translational modifications, the number of synaptic AMPA receptors, and auxiliary proteins. Functional AMPA receptors are located predominantly in the post-synapse but are also found at extra-synaptic sites and occasionally in the pre-synapse. Thus, many factors influence the tasks of AMPA receptors in neuronal signal transmission. At hippocampal synaptic connections, AMPA receptor functions have been well studied in vitro and in the mouse; however, it is unlikely that these observations can be generalized to all glutamatergic synapses in the brain.
引用
收藏
页码:447 / 455
页数:9
相关论文
共 50 条
  • [21] Synaptic plasticity in mice expressing genetically manipulated AMPA receptors
    Sprengel, R
    Zamanillo, D
    Brusa, R
    Hvalby, O
    Seeburg, B
    Sakmann, B
    BRAIN RESEARCH, 1998, 809 (01) : A21 - A21
  • [22] Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning
    Zamanillo, D
    Sprengel, R
    Hvalby, O
    Jensen, V
    Burnashev, N
    Rozov, A
    Kaiser, KMM
    Köster, HJ
    Borchardt, T
    Worley, P
    Lübke, J
    Frotscher, M
    Kelly, PH
    Sommer, B
    Andersen, P
    Seeburg, PH
    Sakmann, B
    SCIENCE, 1999, 284 (5421) : 1805 - 1811
  • [23] Role of AMPA receptor cycling in synaptic transmission and plasticity
    Lüscher, C
    Xia, HH
    Beattie, EC
    Carroll, RC
    von Zastrow, M
    Malenka, RC
    Nicoll, RA
    NEURON, 1999, 24 (03) : 649 - 658
  • [24] Participation of Ca2+-Permeable AMPA Receptors in Synaptic Plasticity
    Dolgacheva, L. P.
    Tuleukhanov, S. T.
    Zinehenko, V. P.
    BIOLOGICHESKIE MEMBRANY, 2020, 37 (03): : 175 - 187
  • [25] Participation of Ca2+-Permeable AMPA Receptors in Synaptic Plasticity
    L. P. Dolgacheva
    S. T. Tuleukhanov
    V. P. Zinchenko
    Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 2020, 14 : 194 - 204
  • [26] Ca2+-permeable AMPA receptors in homeostatic synaptic plasticity
    Lee, Hey-Kyoung
    FRONTIERS IN MOLECULAR NEUROSCIENCE, 2012, 5
  • [27] Visualization of AMPA receptors around postsynaptic membrane during synaptic plasticity
    Hirano, Tomoo
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013, 63 : S37 - S37
  • [28] Non-scaling regulation of AMPA receptors in homeostatic synaptic plasticity
    Wang, Guan
    Zhong, Jia
    Guttieres, Donovan
    Man, Heng-Ye
    NEUROPHARMACOLOGY, 2019, 158
  • [29] A biophysical model of bidirectional synaptic plasticity: Dependence on AMPA and NMDA receptors
    Castellani, GC
    Quinlan, EM
    Cooper, LN
    Shouval, HZ
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (22) : 12772 - 12777
  • [30] Participation of Ca2+-Permeable AMPA Receptors in Synaptic Plasticity
    Dolgaeheva, L. P.
    Tuleukhanov, S. T.
    Zinchenko, V. P.
    BIOCHEMISTRY MOSCOW SUPPLEMENT SERIES A-MEMBRANE AND CELL BIOLOGY, 2020, 14 (03) : 194 - 204