A new entry to phenanthridine ring systems via sequential application of Suzuki and the modified Pictet-Spengler reactions

被引：44

作者：

Mandadapu, Anil K. ^{[1
]}

Saifuddin, Mohammad ^{[1
]}

Agarwal, Piyush K. ^{[1
]}

Kundu, Bijoy ^{[1
]}

机构：

[1] Cent Drug Res Inst, Div Med & Proc Chem, Lucknow 226001, Uttar Pradesh, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 13期

关键词：

6-SUBSTITUTED PHENANTHRIDINES; CYCLIZATION REACTIONS; CONCISE SYNTHESIS; ANTITUMOR AGENTS; ORTHO-ARYLATION; EFFICIENT; ANTIMALARIAL; FAGARONINE; ALKALOIDS; NITIDINE;

D O I：

10.1039/b905696c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild, efficient and versatile method has been developed for the two step synthesis of phenanthridine ring systems using the Suzuki and the modified Pictet-Spengler strategy. The strategy involves synthesis of a substrate in which an aryl amine is tethered to an activated arene ring at the carbon ortho to the activated carbon nucleophile so as to facilitate the formation of phenanthridine ring via pi-cyclization.

引用

页码：2796 / 2803

页数：8

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