Effects of calorie restriction with n-3 long-chain polyunsaturated fatty acids on metabolic syndrome severity in obese subjects: A randomize-controlled trial

被引：19

作者：

Lee, Hsiu-Chuan ^{[1
,2
]}

Cheng, Wen-Yi ^{[1
]}

Hsu, Yi-Hao ^{[1
]}

Su, Hsiu-Yueh ^{[1
,3
]}

Huang, Brian E. T. -G. ^{[4
]}

Lin, Yen-Kuang ^{[5
]}

Chan, Wing P. ^{[6
]}

Su, Chien-Tien ^{[7
]}

Huang, Shih-Yi ^{[1
]}

机构：

[1] Taipei Med Univ, Sch Nutr & Hlth Sci, Taipei 110, Taiwan

[2] Taipei Med Univ, Program Translat Med, Taipei 110, Taiwan

[3] Taipei Med Univ, Taipei Med Univ Hosp, Dept Dietet, Taipei 110, Taiwan

[4] Natl Taiwan Univ, Dept Chem, Taipei 10764, Taiwan

[5] Taipei Med Univ, Biostat Ctr, Taipei 110, Taiwan

[6] Taipei Med Univ, Wan Fang Hosp, Dept Radiol, Taipei 110, Taiwan

[7] Taipei Med Univ, Sch Publ Hlth, Taipei 110, Taiwan

来源：

JOURNAL OF FUNCTIONAL FOODS | 2015年 / 19卷

关键词：

Metabolic syndrome; n-3 long-chain polyunsaturated; fatty acids; n-6/n-3; ratio; INSULIN SENSITIVITY; MEAL REPLACEMENT; CLINICAL-TRIAL; BLOOD-PRESSURE; SERUM-LIPIDS; DOUBLE-BLIND; PROTEIN; PLASMA; TRIGLYCERIDES; DIET;

D O I：

10.1016/j.jff.2015.01.040

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Metabolic syndrome (MetS) increases the risk of type 2 DM and cardiovascular disease. We here evaluated the effects of a calorie-restriction diet with 2.13 g/day n-3 long-chain polyunsaturated fatty acid supplementation in MetS patients. The 188 participants were randomly assigned one of four calorie-restriction diets for 12 weeks: calorie-restriction (n = 44), calorie-restriction meal replacement (n = 45), calorie-restriction with fish oil (n = 44), or calorie-restriction meal replacement with fish oil (n = 44); 179 participants completed the trial. After treatment, all groups had significant reduction in waist circumference, blood pressure, and cardiometabolic parameters. Results indicate that long-chain polyunsaturated fatty acid (LC-PUFA) supplementation under calorie-restriction exert beneficial effects on metabolic parameters. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：929 / 940

页数：12

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