Pannexin: To gap or not to gap, is that a question?

被引:143
作者
Dahl, Gerhard [1 ]
Locovei, Silviu [1 ]
机构
[1] Univ Miami, Sch Med, Dept Physiol & Biophys, Miami, FL 33101 USA
关键词
pannexin; innexin; ATP release; calcium wave; erythrocyte; gap junction;
D O I
10.1080/15216540600794526
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Vertebrates express two families of gap junction proteins: the well characterized connexins and the recently discovered pannexins. The latter are related to invertebrate innexins. Here we present the hypothesis that pannexins, rather than providing a redundant system to gap junctions formed by connexins, exert a physiological role as nonjunctional membrane channels. Specifically, we propose that pannexins can serve as ATP release channels. This function presumptively is also performed by innexins in invertebrates, in addition to their traditional gap junction role.
引用
收藏
页码:409 / 419
页数:11
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